OKADAIC ACID
![OKADAIC ACID Structure](CAS/GIF/78111-17-8.gif)
- CAS No.
- 78111-17-8
- Chemical Name:
- OKADAIC ACID
- Synonyms
- OA;CS-759;NSC 677083;Okadic acid;Ocadaic Acid;OKADAIC ACID;HALOCHONDRINE A;Okadaic acid,97%;35-Demethyl-DTX 1;OKADAIC ACID, 98+%
- CBNumber:
- CB0246204
- Molecular Formula:
- C44H68O13
- Molecular Weight:
- 805
- MOL File:
- 78111-17-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
Melting point | 164-166 °C |
---|---|
alpha | D20 +21° (c = 0.33 in CHCl3); D25 +25.4° (c = 0.24 in CHCl3) |
Boiling point | 672.95°C (rough estimate) |
Density | 1.0795 (rough estimate) |
refractive index | 1.5940 (estimate) |
storage temp. | -20°C |
solubility | DMSO: ≥1 mg/mL |
form | translucent film |
pka | 3.87±0.16(Predicted) |
color | translucent |
Water Solubility | It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol. |
Merck | 13,6891 |
Stability | Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 78111-17-8 |
EPA Substance Registry System | 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, .alpha,5-dihydroxy-.alpha.,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, (.alpha.R,2S,5R,6R,8S)- (78111-17-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331-H315 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 23/24/25-38 | |||||||||
Safety Statements | 26-36/37-45 | |||||||||
RIDADR | UN 3462 6.1/PG 1 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AA8227800 | |||||||||
F | 10 | |||||||||
HazardClass | 6.1(a) | |||||||||
PackingGroup | II | |||||||||
HS Code | 29321900 | |||||||||
Toxicity | LD50 i.p. in mice: 192 mg/kg (Shibata) | |||||||||
NFPA 704 |
|
OKADAIC ACID price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | O9381 | Okadaic acid from Prorocentrum concavum 92-100% (HPLC) | 78111-17-8 | 25μG | ₹32994.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 495604 | Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem Okadaic Acid, CAS 78111-17-8, is a highly potent inhibitor of protein phosphatase 1 (IC?? = 10-15 nM) and 2A (IC?? = 0.1 nM). | 78111-17-8 | 25μG | ₹11880.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | O9381 | Okadaic acid from Prorocentrum concavum 92-100% (HPLC) | 78111-17-8 | 0.1MG | ₹88483.55 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 495604 | Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem Okadaic Acid, CAS 78111-17-8, is a highly potent inhibitor of protein phosphatase 1 (IC?? = 10-15 nM) and 2A (IC?? = 0.1 nM). | 78111-17-8 | 100μG | ₹37040 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 495604 | Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem Okadaic Acid, CAS 78111-17-8, is a highly potent inhibitor of protein phosphatase 1 (IC?? = 10-15 nM) and 2A (IC?? = 0.1 nM). | 78111-17-8 | 500μG | ₹148429.99 | 2022-06-14 | Buy |
OKADAIC ACID Chemical Properties,Uses,Production
Chemical Properties
white crystals or powder
Uses
Okadaic acid is a widely distributed marine toxin produced by several phytoplanktonic species and responsible for diarrheic shellfish poisoning in humans. At the molecular level, Okadaic acid is a pot ent and specific inhibitor of various types of serine/threonine protein phosphatases. Due to this enzymatic inhibition, Okadaic acid was reported to induce numerous alterations in relevant cellular ph ysiological processes, including metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism and glycogen and protein synthesis.
General Description
Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum?and?Dinophysis.
Biological Activity
Potent inhibitor of protein phosphatase 1 (IC 50 = 3 nM) and protein phosphatase 2A (IC 50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promotor. Shown to activate atypical protein kinase C in adipocytes.
Safety Profile
A poison by intraperitoneal route.Questionable carcinogen. Mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating vapors
OKADAIC ACID Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
Naturewill Biotechnology Co., Ltd. | 18113192475 18113192475 | China | 5000 | 58 | Inquiry |
Guangzhou Yaoguang Technology Co., Ltd. | 13020159086 | China | 487 | 58 | Inquiry |
Shanghai Zheyan Biotechnology Co., LTD | 18017610038 18017610038 | China | 5000 | 58 | Inquiry |
Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | China | 29803 | 58 | Inquiry |
Related articles
- What is Okadaic Acid?
- Marine algal blooms, natural phenomena produced by the overgrowth of microscopic marine algae, have become a public health con....
- Oct 13,2021
78111-17-8(OKADAIC ACID)Related Search:
1of4
chevron_right