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R-406

CAS No.: 841290-80-0

Chemical Name:: R-406

Synonyms: R-406;CS-214;R406;R-406;R406(free base);R-406 USP/EP/BP;R406 (Tamatinib);Tamatinib (R-406);SYK Inhibitor R406;FostamatinibImpurity1;R406 (FREE BASE);R-406

CBNumber:: CB02498791

Molecular Formula:: C22H23FN6O5

Molecular Weight:: 470.45

MOL File:: 841290-80-0.mol

Modify Date:: 2023/10/8 17:02:05

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R-406 Properties

Melting point	182-184°C
Density	1.358±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	10.63±0.40(Predicted)
color	Off-White to Light Grey

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08,GHS06

Signal word

Danger

Hazard statements

H301-H361

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501

NFPA 704

	0
2		0

R-406 Chemical Properties,Uses,Production

Uses

Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.

R-406 Preparation Products And Raw materials

Raw materials

Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate

Preparation Products

Fostamatinib

R-406 Suppliers

Global( 160)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29897	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	11506	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

R-406 Spectrum

R-406(841290-80-0)¹HNMR

841290-80-0(R-406)Related Search:

Alisertib (MLN8237) R788(Fostamatinib disodium) Ibrutinib Ruxolitinib R406

R 5011 (dopant) R1011 (R)-2-Octyl 4-[4-(Hexyloxy)benzoyloxy]benzoate Sodium dodecyl sulfate Tofacitinib citrate

Bortezomib

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R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one R406(free base) R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one R406 (free base), >=98% R406 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one R406 (FREE BASE);R-406 6-(5-Fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][ Tamatinib (R-406) TamatinibQ: What is Tamatinib Q: What is the CAS Number of Tamatinib Q: What is the storage condition of Tamatinib R406 (Tamatinib) R406;R-406 CS-214 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl- Fostamatinib (free base) R-406 USP/EP/BP FostamatinibImpurity1 SYK Inhibitor R406 841290-80-0 C22H23FN6O5 Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API