N-OXALYL GLYCINE
- CAS No.
- 5262-39-5
- Chemical Name:
- N-OXALYL GLYCINE
- Synonyms
- NOG;SYM1;SYNS1;N-OXALYL GLYINE;N-OXALYL GLYCINE;Mouse bearing tumor;N-Oxalylglycine (NOG);In vivo drug screening;Tumor modeling services;Human NOG Protein, Fc Tag
- CBNumber:
- CB0250467
- Molecular Formula:
- C4H5NO5
- Molecular Weight:
- 147.09
- MOL File:
- 5262-39-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:54:57
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol(GHS) | GHS07 |
|||||||||
| Signal word | Warning | |||||||||
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
N-OXALYL GLYCINE price More Price(2)
N-OXALYL GLYCINE Chemical Properties,Uses,Production
Uses
The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells. Because histone demethylases are implicated in certain diseases, including cancer, selective inhibitors are candidate anticancer agents as well as potential tools for elucidating the biological functions of JMJDs. N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC50s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC50 values of 2.1 and 5.6 μM, respectively.[Cayman Chemical]
Definition
ChEBI: An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes.
Biochem/physiol Actions
N-Oxalylglycine is an inhibitor of α-ketoglutarate-dependent enzymes and mimics the initial steps but does not initiate the hydroxylation process. N-Oxalylglycine has been used to inhibit Jumonji C-domain-containing histone lysine demethylases.
N-OXALYL GLYCINE Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| CR Corporation Limited | +8613062833949 | China | 8647 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | China | 4874 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| Dideu Industries Group Limited | 58 |
| Finetech Industry Limited | 58 |
| CR Corporation Limited | 58 |
| Nextpeptide Inc | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | 58 |