VERRUCULOGEN
- CAS No.
- 12771-72-1
- Chemical Name:
- VERRUCULOGEN
- Synonyms
- tr1;T1R1;TRXR1;GPR70;TAS1R1;NA 209A;GRIM-12;MGC9145;TR-1TOXIN;VERRUCOLOGEN
- CBNumber:
- CB0294003
- Molecular Formula:
- C27H33N3O7
- Molecular Weight:
- 511.57
- MOL File:
- 12771-72-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
Boiling point | 738.4±60.0 °C(Predicted) |
---|---|
Density | 1.49±0.1 g/cm3(Predicted) |
Flash point | 2℃ |
storage temp. | 2-8°C |
solubility | Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide |
form | buffered aqueous solution |
pka | 10?+-.0.70(Predicted) |
color | White to off-white |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H302+H312+H332-H319 | |||||||||
Precautionary statements | P210-P261-P280-P305+P351+P338-P370+P378-P403+P235 | |||||||||
Hazard Codes | T,Xn,F | |||||||||
Risk Statements | 23/24/25-36-20/21/22-11 | |||||||||
Safety Statements | 36/37/39-45-36/37-26-16 | |||||||||
RIDADR | UN 2811 6.1/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | JH4920000 | |||||||||
HS Code | 38220090 | |||||||||
NFPA 704 |
|
VERRUCULOGEN price More Price(1)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SAB1304378 | ANTI-TAS1R1 (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 12771-72-1 | 400μL | ₹47796.6 | 2022-06-14 | Buy |
Product number | Packaging | Price | Buy |
---|---|---|---|
SAB1304378 | 400μL | ₹47796.6 | Buy |
VERRUCULOGEN Chemical Properties,Uses,Production
Uses
Verruculogen is a tremorgenic mycotoxin, first isolated from Penicillium verruculosum in 1972. The structure was resolved as an indole alkaloid in 1974. Verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels, and is a cell cycle inhibitor blocking division at the M phase.
Definition
ChEBI: An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.
Biochem/physiol Actions
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
VERRUCULOGEN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
Shanghai klamar Reagent Co., LTD | 4001650900 13817534909 | China | 10709 | 58 | Inquiry |
Wuhan Dingxintong Pharmaceutical Co. , Ltd. | 027-027-52344656 15871722230 | China | 3664 | 58 | Inquiry |
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