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VERRUCULOGEN

VERRUCULOGEN Structure
CAS No.
12771-72-1
Chemical Name:
VERRUCULOGEN
Synonyms
tr1;T1R1;TRXR1;GPR70;TAS1R1;NA 209A;GRIM-12;MGC9145;TR-1TOXIN;VERRUCOLOGEN
CBNumber:
CB0294003
Molecular Formula:
C27H33N3O7
Molecular Weight:
511.57
MOL File:
12771-72-1.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59

VERRUCULOGEN Properties

Boiling point 738.4±60.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
Flash point 2℃
storage temp. 2-8°C
solubility Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
form buffered aqueous solution
pka 10?+-.0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P261-P280-P305+P351+P338-P370+P378-P403+P235
Hazard Codes  T,Xn,F
Risk Statements  23/24/25-36-20/21/22-11
Safety Statements  36/37/39-45-36/37-26-16
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  JH4920000
HS Code  38220090
NFPA 704
0
4 0

VERRUCULOGEN price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SAB1304378 ANTI-TAS1R1 (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 12771-72-1 400μL ₹47796.6 2022-06-14 Buy
Product number Packaging Price Buy
SAB1304378 400μL ₹47796.6 Buy

VERRUCULOGEN Chemical Properties,Uses,Production

Uses

Verruculogen is a tremorgenic mycotoxin, first isolated from Penicillium verruculosum in 1972. The structure was resolved as an indole alkaloid in 1974. Verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic marker. The tremorgenic action of verruculogen is associated with increases in spontaneous glutamate and aspartate release, decreases in GABA levels and, at toxic doses, an increase in the number and decrease in the affinity of DHP receptors in rat cortex. In in vitro guinea pig ileum preparations, verruculogen causes an increase in contractile responses due to electrical field stimulation, attributed to enhancement of acetylcholine from presynaptic nerve terminals. Verruculogen also inhibits Ca2+-activated K+ channels, and is a cell cycle inhibitor blocking division at the M phase.

Definition

ChEBI: An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.

Biochem/physiol Actions

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

VERRUCULOGEN Preparation Products And Raw materials

Raw materials

Preparation Products

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VERRUCULOGEN VERRUCULOGEN, PENICILLIUM VERRUCULOSUM 3h)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimeth 5h,12h-3,4-dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2h,1 tr1 verruculogentr1 yl-5-(2-methyl-1-propenyl)-,(5r-(5-alpha,10-alpha,10a-alpha,14a-alpha-15b-alp verruculogen from penicillium*verruculosum VERRUCULOGEN FROM PENICILLIUM VERRUCULOS VERRUCOLOGEN TR-1TOXIN (5R)-1,10,10a,14,14aα,15bα-Hexahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-12H-3,4-dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione (5R)-2,5,10,10a,11,12,13,14,14aα,15bα-Decahydro-10α,10aα-dihydroxy-7-methoxy-2,2-dimethyl-5α-(2-methyl-1-propenyl)-3,4-dioxa-5a,11a,15a-triaza-1H-cyclooct[lm]indeno[5,6-b]fluorene-11,15-dione (5R-(5alpha,10 alpha,10Aalpha,14aalpha,15balpha))-1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-5H,12H-3,4-dioxa-5A,11A,15A-triaza cyclooct (1m) indeno (5,6-B)fluorene-11,15(2H,13H)-dione 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-, (5R,10S,10ar,14as,15bs)- 5H,12H-3,4-Dioxa-5A,11A,15A-triazacyclooct(lm)indeno(5,6-B)fluorene-11,15(2H,13H)-dione, 1,10,10A,14,14A,15B-hexahydro-10,10A-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R-(5-alpha,10-alpha,10A-alpha,14A-alpha-15B-alpha))- Verruculogenresearch grade NA 209A Verruculogen NA 209A TR 1 toxin Verruculogen solution GRIM-12 MGC9145 TRXR1 TXNRD1 human Anti-TAS1R1 (N-terminal) antibody produced in rabbit GPR70 T1R1 TAS1R1 ANTI-TAS1R1 (CENTER) antibody produced in rabbit Taste receptor type 1 member 1 Anti-TAS1R1 (C-terminal) antibody produced in rabbit GWIWVUJHTCZBOP-FCXIIMTCSA-N 5H,12H-3,4-Dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-, (5R,10S,10aR,14aS,15bS)- 12771-72-1 C27H35N3O7 C27H33N3O7 antibiotic