Sacubitril Sodium
- CAS No.
- 149690-05-1
- Chemical Name:
- Sacubitril Sodium
- Synonyms
- Sacubitril sodium;Valsartan Sodium;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
- CBNumber:
- CB03069990
- Molecular Formula:
- C24H28NNaO5
- Molecular Weight:
- 433.47259
- MOL File:
- 149690-05-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/22 11:23:49
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H413 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
Sacubitril Sodium Chemical Properties,Uses,Production
Description
Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.
Uses
Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Sacubitril Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Mankind Pharma Limited | +91-1146541111 +91-1146541111 | New Delhi, India | 23 | 58 | Inquiry |
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Ami Lifesciences Pvt Ltd | +91-9426998100 +91-9426998100 | Gujarat, India | 62 | 58 | Inquiry |
| NK Chemiosys Pvt Ltd | +91-9585456771 +91-9787530913 | Tamil Nadu, India | 17 | 58 | Inquiry |
| RAKS PHARMA PVT LTD | +91 891 3081555 | New Delhi, India | 65 | 58 | Inquiry |
| MSN LIFE SCIENCES PRIVATE LTD | +91 84523 34200 | New Delhi, India | 104 | 58 | Inquiry |
| BIOCON LTD | +91 80 2808 2808 | New Delhi, India | 39 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
149690-05-1(Sacubitril Sodium )Related Search:
LCZ696(valsartan + sacubitril) impurity 35
[1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)-
LCZ696(valsartan + sacubitril) impurity 31
[1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)-
LCZ696(valsartan + sacubitril) impurity 34
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Sacubitril Sodium Salt
Valsartan Sodium
sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
AHU-377 (Sacubitril free base)
Sacubitril sodium
AHU-377 sodium salt
Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
Thacubatra sodium
(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
149690-05-1