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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >BMS-986205

BMS-986205

BMS-986205 Structure
CAS No.
1923833-60-6
Chemical Name:
BMS-986205
Synonyms
Linrodostat;CS-2743;F001287;F-001287;BMS-986205;BMS 986205;BMS986205;Linrodostat（BMS-986205）;BMS-986205(Linrodostat);LINRODOSTAT;BMS 986205;BMS986205;(2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamid
CBNumber:
CB03339862
Molecular Formula:
C24H24ClFN2O
Molecular Weight:
410.91
MOL File:
1923833-60-6.mol
Modify Date:
2024/7/2 8:54:58
Request For Quotation

BMS-986205 Properties

Boiling point 606.8±45.0 °C(Predicted)
Density 1?+-.0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)
form Solid
pka 13.80±0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

BMS-986205 Chemical Properties,Uses,Production

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

BMS-986205 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-986205 Suppliers

Global( 100)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Hangzhou Proserre Chemical Co.,Ltd. +86-571-86088112 China 1077 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3581 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
Hangzhou Proserre Chemical Co.,Ltd. 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Hebei Miaoyin Technology Co.,Ltd 58

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BMS-986205 LINRODOSTAT;BMS 986205;BMS986205 BMS 986205;BMS986205 BMS-986205(Linrodostat) CS-2743 (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamid Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-α-methyl-, cis-(αR)- Linrodostat (R)-N-(4-Chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Linrodostat（BMS-986205） cis-(αR)-N-(4-Chlorophenyl)-4-(6-fluoro-4-quinolinyl)-α-methylcyclohexaneacetamide cis-(alphaR)-N-(4-Chlorophenyl)-4-(6-fluoro-quinolin-4-yl)-alpha-methylcyclohexaneacetamide F001287 F-001287 1923833-60-6 923833-60-6 C24H24ClFN2O API