2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
![2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Structure](CAS/GIF/321674-73-1.gif)
- CAS No.
- 321674-73-1
- Chemical Name:
- 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
- Synonyms
- CS-1061;BIBR 1532;BIBR 1532, >=98%;BIBR 1532;BIBR-1532;Telomerase Inhibitor X;(E)-2-(3-phenylbut-2-enamido)benzoic acid;2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID;(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid;2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid;2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
- CBNumber:
- CB62456353
- Molecular Formula:
- C21H17NO3
- Molecular Weight:
- 331.36
- MOL File:
- 321674-73-1.mol
- Modify Date:
- 2023/6/30 15:45:59
Melting point | >173oC (dec.) |
---|---|
Boiling point | 600.6±48.0 °C(Predicted) |
Density | 1.284 |
storage temp. | Store at RT |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Solid |
pka | 3.46±0.36(Predicted) |
color | White to Off-White |
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID price More Price(1)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 5.08839 | Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem A cell-permeable, selective, highly potent, non-nucleotide competitive inhibitor of telomerase activity (IC?? = 93 nM in HeLa cells nuclear extracts). | 321674-73-1 | 10MG | ₹17660.01 | 2022-06-14 | Buy |
Product number | Packaging | Price | Buy |
---|---|---|---|
5.08839 | 10MG | ₹17660.01 | Buy |
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Chemical Properties,Uses,Production
Description
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.
Biological Activity
Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18646 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
CD Chemical Group Limited | +8615986615575 | China | 20356 | 58 | Inquiry |
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