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MKC9989

MKC9989 Structure
CAS No.
1338934-20-5
Chemical Name:
MKC9989
Synonyms
MKC9989;Inhibitor,Inositol requiring enzyme 1,MKC-9989,inhibit,MKC9989,IRE1,MKC 9989;7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2H-chromene-8-carbaldehyde;2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxo-
CBNumber:
CB03386497
Molecular Formula:
C17H20O7
Molecular Weight:
336.34
MOL File:
1338934-20-5.mol
Modify Date:
2024/7/2 8:54:58
Request For Quotation

MKC9989 Properties

storage temp. Store at -20°C
solubility DMSO : ≥ 50 mg/mL (148.66 mM);Water : < 0.1 mg/mL (insoluble)
form Solid
color Light yellow to yellow

MKC9989 Chemical Properties,Uses,Production

Reactions

From a functional point of the view, the MKC9989 inhibitor belongs to a series of IRE1 RNase inhibitors termed hydroxy aryl aldehydes (HAA) where the aldehyde moiety reacts chemically with the amine side chain of K907 through a Schiff base reaction[2].

References

[1]. Sanches M, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.
[2] Mahdizadeh S, et al. Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1α; a multiscale in silico approach. RSC Advances, 2020; 10: 19720-19729.

MKC9989 Preparation Products And Raw materials

Raw materials

Preparation Products

MKC9989 Suppliers

Global( 16)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shanghai Gubang New Materail Technology Co. LTD 21-51317962 +8618721305404 CHINA 272 58 Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 China 11289 58 Inquiry
Aikon International Limited 18626450290 China 10718 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23963 58 Inquiry
Twochem Co.Ltd. 021-58111628 15800915896 China 1789 58 Inquiry
Shanghai Gugang New Materials Technology Co. Ltd. 021-51317962 China 974 58 Inquiry
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 China 9771 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Shanghai Qiming Biological Technology Co., Ltd. 021-61483491 CHINA 6503 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Shanghai Gubang New Materail Technology Co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Aikon International Limited 58
TargetMol Chemicals Inc. 58
Twochem Co.Ltd. 58
Shanghai Gugang New Materials Technology Co. Ltd. 58
Shanghai Zeye Biotechnology Co., Ltd. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Shanghai Qiming Biological Technology Co., Ltd. 58

MKC9989 Spectrum

MKC9989(1338934-20-5)1HNMR

1338934-20-5(MKC9989)Related Search:

MKC8866 MK-8998 MK-4101 MK8745 MK-3903
mk-1064 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK 0557 MK-0812 (Succinate) MKC3946
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MKC9989 7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxo- Inhibitor,Inositol requiring enzyme 1,MKC-9989,inhibit,MKC9989,IRE1,MKC 9989 1338934-20-5