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MK 0557

MK 0557 Structure
CAS No.
328232-95-7
Chemical Name:
MK 0557
Synonyms
MK 0557;CS-2471;MK0557;MK 0557;MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557;N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester;N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide;trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
CBNumber:
CB32628133
Molecular Formula:
C22H19FN4O3
Molecular Weight:
406.41
MOL File:
328232-95-7.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06
Request For Quotation

MK 0557 Properties

Melting point 240.0-240.6 °C
Boiling point 708.7±60.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form A crystalline solid
pka 13.40±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

MK 0557 Chemical Properties,Uses,Production

Description

MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.

MK 0557 Preparation Products And Raw materials

Raw materials

Preparation Products

MK 0557 Suppliers

Global( 53)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Beijing Baiao Innovation Technology Co., Ltd. 010-5718533 13366620421 CHINA 6005 58 Inquiry
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4287 55 Inquiry
Supplier Advantage
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Amadis Chemical Company Limited 58
Beijing Baiao Innovation Technology Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55

328232-95-7(MK 0557)Related Search:

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MK 0557 trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide (1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans- MK0557;MK 0557 CS-2471 N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557 trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide 328232-95-7 28232-95-7