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Omarigliptin (MK-3102)

CAS No.: 1226781-44-7

Chemical Name:: Omarigliptin (MK-3102)

Synonyms: OMarigliptin;MK-3102;MK-3102(OMARIGLIPTIN);MK-3012;CS-1519;Oralliptin;MK-3102, >=98%;MK 3102:MK-3102;MK-3102 - M10588;OMarigliptin (MK-3102)

CBNumber:: CB12516047

Molecular Formula:: C17H20F2N4O3S

Molecular Weight:: 398.43

MOL File:: 1226781-44-7.mol

MSDS File:: SDS

Modify Date:: 2024/8/5 12:01:54

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Omarigliptin (MK-3102) Properties

Boiling point	529.4±60.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	insoluble in EtOH; insoluble in H2O; ≥17.15 mg/mL in DMSO
form	solid
pka	9.11±0.60(Predicted)
color	White to off-white
InChI	InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
InChIKey	MKMPWKUAHLTIBJ-ISTRZQFTSA-N
SMILES	[C@H]1(C2=CC(F)=CC=C2F)OC[C@H](N2CC3=CN(S(C)(=O)=O)N=C3C2)C[C@@H]1N
CAS DataBase Reference	1226781-44-7

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Omarigliptin (MK-3102) Chemical Properties,Uses,Production

Description

Merck earned its first global approval for omarigliptin in Japan in 2015, and phase III development is ongoing in other countries around the globe for this interesting small molecule DPP-4 inhibitor. Interestingly, while most DPP-4 inhibitors used to treat type 2 DM require daily administration, omarigliptin is a weekly treatment. The process-scale synthesis of omarigliptin has been nicely described in an October 2015 paper from the Merck process group.

Uses

Omarigliptin is a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as treatment for type 2 diabetes.

Omarigliptin (MK-3102) Preparation Products And Raw materials

Raw materials

Preparation Products

Omarigliptin (MK-3102) Suppliers

Global( 243)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	990	58	Inquiry
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	China	227	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	China	3878	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21667	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9343	55	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Hangzhou ICH Biofarm Co., Ltd	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55

Omarigliptin (MK-3102) Spectrum

Omarigliptin (MK-3102)(1226781-44-7)¹HNMR

1226781-44-7(Omarigliptin (MK-3102))Related Search:

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(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine MK-3012 (2S,3R,5S)-2-(2,5-Difluorophenyl)-5-[2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-aMine (MK-3102 enantioMer) (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine OMarigliptin (MK-3102) 2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine MK3102 MK-3102 - M10588 MK-3102, >=98% MK-3102 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)te Omarigliptin, 98%, a potent, selective and long-acting DPP-4 inhibitor Oralliptin MK-3102;MK3102;MK 3102 CS-1519 MK-3102, Omarigliptin [USAN], Omarigliptin (USAN/INN), SureCN827590, UNII-CVP59Q4JE1, CHEMBL2105762, MK-3102, PB39113 (2R,3S,5R)-2-(2,5-DIFLUOROPHENYL)- 5-[2-(METHYLSULFONYL)-2,6- DIHYDROPYRROLO[3,4-C]PYRAZOL-5(4H)- YL (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine 2H-Pyran-3-amine, 2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-, (2R,3S,5R)- Omarigliptin (MK-3102)Q: What is Omarigliptin (MK-3102) Q: What is the CAS Number of Omarigliptin (MK-3102) Q: What is the storage condition of Omarigliptin (MK-3102) MK-3102 OMarigliptin MK-3102(OMARIGLIPTIN) MK 3102:MK-3102 1226781-44-7 C17H20F2N4O3S Inhibitors API