MK-1775
![MK-1775 Structure](CAS2/GIF/955365-80-7.gif)
- CAS No.
- 955365-80-7
- Chemical Name:
- MK-1775
- Synonyms
- AZD1775;CS-605;101254;MK-1775;MK-1175;MK-1755;Adavosertib);MK-1775, >=98%;MK-1775,MK1775;MK-1775, AZD1775,
- CBNumber:
- CB82514921
- Molecular Formula:
- C27H32N8O2
- Molecular Weight:
- 500.6
- MOL File:
- 955365-80-7.mol
- Modify Date:
- 2024/6/26 14:33:32
Melting point | 179-181°C |
---|---|
Boiling point | 723.8±70.0 °C(Predicted) |
Density | 1.292 |
storage temp. | -20°C |
solubility | Soluble in DMSO (70 mg/ml) |
form | solid |
pka | 13.27±0.29(Predicted) |
color | Yellow |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
InChIKey | BKWJAKQVGHWELA-UHFFFAOYSA-N |
SMILES | C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3=NC(C(O)(C)C)=CC=C3)C2=N1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
MK-1775 Chemical Properties,Uses,Production
Description
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
Uses
MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.
Clinical Use
MK-1775 is a novel, potent and selective Wee1 kinase inhibitor used in clinical studies for the treatment of a variety of solid tumours (including lymphoma, multiple myeloma, oropharyngeal, cervical, vaginal and ovarian cancers). Nanomolar concentrations of MK-1775 radiosensitised p53-deficient human lung, breast and prostate cancer cells, but did not radiosensitise similar cell lines with wild-type p53. Consistent with the radiosensitising ability, MK-1775 attenuated radiation-induced G2 block in p53-deficient cells, whereas p53 wild-type cell lines did not. MK-1775 also significantly enhanced the anti-tumour efficacy of radiation in vivo in tumour growth delay studies, which also applied to p53-deficient tumours.
Side effects
Common side effects of Adavosertib (MK-1775) when used alone or in combination with other chemotherapy drugs include: nausea, vomiting, anaemia, diarrhoea, loss of appetite, decreased white blood cell count, decreased platelet count, and fever. Other side effects that may occur are: constipation, rectal pain, anaemia, diarrhoea. Severe febrile neutropenia, hypophosphatemia, acute respiratory distress syndrome and interstitial pneumonia can result. Contact your doctor if any of these serious adverse reactions occur.
MK-1775 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | China | 5225 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7621 | 58 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7121 | 58 | Inquiry |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |