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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Hydroxypyridine >MK-1775

MK-1775

MK-1775 Structure
CAS No.
955365-80-7
Chemical Name:
MK-1775
Synonyms
AZD1775;CS-605;101254;MK-1775;MK-1175;MK-1755;Adavosertib);MK-1775, >=98%;MK-1775,MK1775;MK-1775, AZD1775,
CBNumber:
CB82514921
Molecular Formula:
C27H32N8O2
Molecular Weight:
500.6
MOL File:
955365-80-7.mol
Modify Date:
2024/6/26 14:33:32
Request For Quotation

MK-1775 Properties

Melting point 179-181°C
Boiling point 723.8±70.0 °C(Predicted)
Density 1.292
storage temp. -20°C
solubility Soluble in DMSO (70 mg/ml)
form solid
pka 13.27±0.29(Predicted)
color Yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey BKWJAKQVGHWELA-UHFFFAOYSA-N
SMILES C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3=NC(C(O)(C)C)=CC=C3)C2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

MK-1775 Chemical Properties,Uses,Production

Description

MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

Uses

MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Clinical Use

MK-1775 is a novel, potent and selective Wee1 kinase inhibitor used in clinical studies for the treatment of a variety of solid tumours (including lymphoma, multiple myeloma, oropharyngeal, cervical, vaginal and ovarian cancers). Nanomolar concentrations of MK-1775 radiosensitised p53-deficient human lung, breast and prostate cancer cells, but did not radiosensitise similar cell lines with wild-type p53. Consistent with the radiosensitising ability, MK-1775 attenuated radiation-induced G2 block in p53-deficient cells, whereas p53 wild-type cell lines did not. MK-1775 also significantly enhanced the anti-tumour efficacy of radiation in vivo in tumour growth delay studies, which also applied to p53-deficient tumours.

Side effects

Common side effects of Adavosertib (MK-1775) when used alone or in combination with other chemotherapy drugs include: nausea, vomiting, anaemia, diarrhoea, loss of appetite, decreased white blood cell count, decreased platelet count, and fever. Other side effects that may occur are: constipation, rectal pain, anaemia, diarrhoea. Severe febrile neutropenia, hypophosphatemia, acute respiratory distress syndrome and interstitial pneumonia can result. Contact your doctor if any of these serious adverse reactions occur.

MK-1775 Preparation Products And Raw materials

Raw materials

6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one 4-(4-Methylpiperazino)aniline 2-allyl-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one 2-(6-broMopyridin-2-yl)propan-2-ol

Preparation Products

MK-1775 Suppliers

Global( 235)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 5225 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 7621 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shanghai UCHEM Inc. +862156762820 +86-13564624040 China 7121 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
Jinan Carbotang Biotech Co.,Ltd. 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Shanghai UCHEM Inc. 58
ANHUI WITOP BIOTECH CO., LTD 58

MK-1775 Spectrum

MK-1775(955365-80-7)1HNMR

955365-80-7(MK-1775)Related Search:

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2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK-1775 MK-1775,MK1775 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775 MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK-1775, >=98% MK-1175 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- MK-1775, AZD1775, 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H- MK1775;AZD-1775;AZD1775;AZD 1775;MK 1775 CS-605 101254 2-ALLYL-1-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL)-6-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)-1H-PYRAZO Adavosertib) 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one Adavosertib (MK-1775) MK-1775(955365-80-7) MK-1775(AZD1775,Adavosertib) AZD1775;MK-1775;MK1775 MK-1775,Adavosertib 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one MK-1775 ISO 9001：2015 REACH 2-Allyl-1-[6-(2-hydroxy-2-propyl)-2-pyridyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrazolo[3,4-d]pyrimidin-3(2H)-one Adavosertib (AZD-1775 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiper... AZD1775 MK-1755 AZD-1775,AZD 1775,MK1775,MK 1775,Adavosertib,Wee1,inhibit,Inhibitor Adavosertib (MK-1775、AZD1775) 955365-80-7 Inhibitors Other APIs API