MK-1775
MK-1775
- CAS:
- 955365-80-7
- MF:
- C27H32N8O2
- MW:
- 500.6
Suppliers by country/region
Company Type
Properties
- Melting point:
- 179-181°C
- Boiling point:
- 723.8±70.0 °C(Predicted)
- Density
- 1.292
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (70 mg/ml)
- form
- solid
- pka
- 13.27±0.29(Predicted)
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- BKWJAKQVGHWELA-UHFFFAOYSA-N
- SMILES
- C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3=NC(C(O)(C)C)=CC=C3)C2=N1
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Use
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
1 India supplier list of "MK-1775"
- Product Name:MK-1775 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089857
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:MK-1775
- Products Intro:Brand:ajchemicals | Product Number:JDH-34023 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:MK-1775
- Products Intro:Purity: 0.98 | Package: 1G：5G
- Company Type: Trader
- Country/Region: CHINA
- Main Products: MRTX1133,(cas:2055858-27-8)1,1′-Sulfinylbis[3,5-difluorobenzene,(cas:17220-38-1) 3,4-Diaminofurazane,Mirogabalin besylate,AK2292
- Product Name:MK-1775
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:MK-1775
- Products Intro:Purity: 98% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:MK-1775
- Products Intro:Purity: >98% | Package: 300mg | CustNote: BOC Sciences also provides custom synthesis services for MK-1775.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:mk 1775
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:MK-1775
- Products Intro:Purity: 99% | Package: 1KG;7USD
- Company Type: Trader
- Country/Region: CHINA
$7.00/ 1KG
- Product Name:MK 1775
- Products Intro:Purity: 0.99 | Package: 5g;1g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Bredereck's Reagent,Salicylic Acid,Amino Acids,Bipyridine Derivatives,Phenanthroline Derivatives
- Product Name:MK-1775
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chlorogenic acid,Tea polyphenol,Acacetin,Gentiopicroside,Jatrorrhizine