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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

CAS No.: 694499-26-8

Chemical Name:: 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Synonyms: PON50;SW-53;SWF-53;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-;4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline;4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline

CBNumber:: CB92520701

Molecular Formula:: C13H18F3N3

Molecular Weight:: 273.3

MOL File:: 694499-26-8.mol

MSDS File:: SDS

Modify Date:: 2024/6/25 20:17:06

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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Properties

Boiling point	329.1±42.0 °C(Predicted)
Density	1.227
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.55±0.10(Predicted)
InChI	InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
InChIKey	ZMWAZMYBMAAMAW-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H332-H315-H319-H335
Precautionary statements	P280
HS Code	2933599590

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Uses

4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis

Synthesis_694499-26-8
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).

storage

Store long-term at 2-8°C.

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

GZD 824 GZD856

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Suppliers

Global( 231)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Neochemsys Laboratories Pvt Ltd	+918498007788	Hyderabad, India	93	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	China	140	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
Unibest Industrial Co.,Ltd.	+86-8657427855777 +86-18758850676	China	226	58	Inquiry
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	China	3146	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry

Supplier	Advantage
Neochemsys Laboratories Pvt Ltd	58
CHEMSWORTH	30
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
career henan chemical co	58
PharmOrgSyn Laboratories Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Unibest Industrial Co.,Ltd.	58
Dorne Chemical Technology co. LTD	58
Capot Chemical Co.,Ltd.	60

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Spectrum

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline(694499-26-8)¹HNMR

694499-26-8(4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline)Related Search:

1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE

5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate

2-Methylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 1-Methylpiperazine MK-1775 Niraparib

Ponatinib Hydrochloride Galeterone Ponatinib

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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine BenzenaMine, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)- 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)aniline 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline 95+% 5-Amino-2-[(4-methylpiperazin-1-yl)methyl]benzotrifluoride, 1-[4-Amino-2-(trifluoromethyl)benzyl]-4-methylpiperazine 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine Ponatinib Impurity 3 Ponatinib int2 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock COA TDS free sample 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline TDS msds coa PON50 4-(4-METHYLPIPERAZINOMETHYL)-3-(TRIFLUOROMETHYL)ANILINE 694499-26-8 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP SWF-53 SW-53 Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoro... 3-(trifluoromethyl)-4-((4-methylpiperazin-1-yl)methyl)benzenamine 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline-d8 4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline 1-[4-Amino-2-(Trifluoromethyl)benzyl]-4-MethylPiperazine 4-(4-Methylpiperazinomethyl)-3- Pralsetinib Impurity 1 Intermediate of Ponatinib 694499-26-8