4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
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- CAS-Nr.
- 694499-26-8
- Englisch Name:
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- Synonyma:
- PON50;SW-53;SWF-53;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-;4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline;4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
- CBNumber:
- CB92520701
- Summenformel:
- C13H18F3N3
- Molgewicht:
- 273.3
- MOL-Datei:
- 694499-26-8.mol
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Eigenschaften
- Siedepunkt:
- 329.1±42.0 °C(Predicted)
- Dichte
- 1.227
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.55±0.10(Predicted)
- InChI
- InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
- InChIKey
- ZMWAZMYBMAAMAW-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.
Synthese
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).
Lager
Store long-term at 2-8°C.
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 238)Lieferanten
694499-26-8()Verwandte Suche:
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
- 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
- 4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine
- BenzenaMine, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)-
- 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)aniline
- 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline 95+%
- 5-Amino-2-[(4-methylpiperazin-1-yl)methyl]benzotrifluoride, 1-[4-Amino-2-(trifluoromethyl)benzyl]-4-methylpiperazine
- 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
- Ponatinib Impurity 3
- Ponatinib int2
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock COA TDS free sample
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline TDS msds coa
- PON50
- 4-(4-METHYLPIPERAZINOMETHYL)-3-(TRIFLUOROMETHYL)ANILINE 694499-26-8
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP
- SWF-53
- SW-53
- Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoro...
- 3-(trifluoromethyl)-4-((4-methylpiperazin-1-yl)methyl)benzenamine
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline-d8
- 4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
- 1-[4-Amino-2-(Trifluoromethyl)benzyl]-4-MethylPiperazine
- 4-(4-Methylpiperazinomethyl)-3-
- Pralsetinib Impurity 1
- Intermediate of Ponatinib
- 694499-26-8
