2-Chloro-6-methylaniline
- CAS No.
- 87-63-8
- Chemical Name:
- 2-Chloro-6-methylaniline
- Synonyms
- 6-CHLORO-O-TOLUIDINE;6-CHLORO-2-METHYLANILINE;6COT;NSC 60121;oro-6-methyL;TIMTEC-BB SBB004153;6-chloro-o-toluidin;2-Chloro-6-methylani;6-CHLORO-2-TOLUIDINE;6-ChIoro-o-toluidine
- CBNumber:
- CB0361613
- Molecular Formula:
- C7H8ClN
- Molecular Weight:
- 141.6
- MOL File:
- 87-63-8.mol
- Modify Date:
- 2024/2/20 10:02:12
| Melting point | 10-12 °C(lit.) |
|---|---|
| Boiling point | 215 °C(lit.) |
| Density | 1.152 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 210 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 2.51±0.10(Predicted) |
| color | Clear Colourless to Pale Purple |
| Water Solubility | Immiscible |
| BRN | 774624 |
| InChIKey | WFNLHDJJZSJARK-UHFFFAOYSA-N |
| CAS DataBase Reference | 87-63-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenamine, 2-chloro-6-methyl-(87-63-8) |
| EPA Substance Registry System | 6-Chloro-2-methylaniline (87-63-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H341-H373-H410 | |||||||||
| Precautionary statements | P201-P273-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 3429 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XU5100000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214300 | |||||||||
| NFPA 704 |
|
2-Chloro-6-methylaniline price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C51008 | 2-Chloro-6-methylaniline 98% | 87-63-8 | 1G | ₹2413.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A1959 | 2-Chloro-6-methylaniline min. 98.0 % | 87-63-8 | 5G | ₹5000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1959 | 2-Chloro-6-methylaniline min. 98.0 % | 87-63-8 | 25G | ₹10800 | 2022-05-26 | Buy |
2-Chloro-6-methylaniline Chemical Properties,Uses,Production
Description
2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.
Chemical Properties
clear yellow to red-brown liquid
Uses
2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate.
Preparation
A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.
Potential Exposure
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.
Shipping
UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials
Incompatibilities
Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.
2-Chloro-6-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Credas Labs Pvt Ltd | +91 9133918031 | Hyderabad, India | 119 | 58 | Inquiry |
| SPD CHEMICALS | +91-7075800742 +91-7075800742 | Hyderabad, India | 214 | 58 | Inquiry |
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| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Credas Labs Pvt Ltd | 58 |
| SPD CHEMICALS | 58 |
| AATAMI Molecular Research Laboratories Pvt Ltd (AMRL) | 58 |
| Prodev Pharma Pvt Ltd | 58 |
| Opulent Pharma | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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