1,3,5-Trimethoxybenzene
- CAS No.
- 621-23-8
- Chemical Name:
- 1,3,5-Trimethoxybenzene
- Synonyms
- Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
- CBNumber:
- CB0371005
- Molecular Formula:
- C9H12O3
- Molecular Weight:
- 168.19
- MOL File:
- 621-23-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 50-53 °C (lit.) |
|---|---|
| Boiling point | 255 °C (lit.) |
| Density | 1,126g/cm |
| refractive index | 1,533 |
| Flash point | 186 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to cream |
| Water Solubility | insoluble |
| BRN | 1307993 |
| InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N |
| LogP | 1.605 (est) |
| CAS DataBase Reference | 621-23-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,3,5-Trimethoxybenzene(621-23-8) |
| EPA Substance Registry System | 1,3,5-Trimethoxybenzene (621-23-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn,F | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| RIDADR | 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DC2810000 | |||||||||
| Hazard Note | Flammable Solid/Harmful | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| NFPA 704 |
|
1,3,5-Trimethoxybenzene price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus?, ≥99% | 621-23-8 | 10G | ₹2024.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus?, ≥99% | 621-23-8 | 50G | ₹6830.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 74599 | 1,3,5-Trimethoxybenzene Standard for quantitative NMR, TraceCERT? | 621-23-8 | 1G | ₹13834.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 138827 | 1,3,5-Trimethoxybenzene ReagentPlus?, ≥99% | 621-23-8 | 250G | ₹20242.75 | 2022-06-14 | Buy |
| ALFA India | ALF-A13981-30 | 1,3,5-Trimethoxybenzene, 99% | 621-23-8 | 250g | ₹20424 | 2022-05-26 | Buy |
1,3,5-Trimethoxybenzene Chemical Properties,Uses,Production
Chemical Properties
white to cream crystalline powder. Insoluble in water.
Uses
1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.
Definition
ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.
General Description
1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.
Synthesis
A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).
Solubility in organics
Soluble in Methanol, Ether, Ethanol, Benzene.
Solubility in water
Insoluble
Purification Methods
Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]
1,3,5-Trimethoxybenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| INVENTAA INDUSTRIES PRIVATE LIMITED | +91-9849198899 +91-8678274993 | AndhraPradesh, India | 1 | 58 | Inquiry |
| Manav Drugs Pvt. Ltd. | 91-22-65305000 | Maharashtra, India | 78 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Keysource Molecules | 91-9594999721 | Maharashtra, India | 24 | 58 | Inquiry |
| Kkyemistry (india) Pvt., Ltd. | 91-79-6549610 | Gujarat, India | 163 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| Avra Synthesis Pvt Ltd | +914027175796 | New Delhi, India | 1606 | 30 | Inquiry |
Related articles
- 1,3,5-Trimethoxybenzene: Role in Oxidation Reactions and its Biosynthesis Method
- 1,3,5-Trimethoxybenzene is vital in photochemical oxidation of alcohols and is biosynthesized from phloroglucinol, impacting o....
- Sep 6，2024
621-23-8(1,3,5-Trimethoxybenzene)Related Search:
1of4
chevron_right