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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >CDK inhibitors >P276

P276

P276 Structure
CAS No.
920113-03-7
Chemical Name:
P276
Synonyms
P276;CS-996;Riviciclib HCl;P276 USP/EP/BP;Riviciclib HCl (P276-00);Riviciclib hydrochloride;RIVICICLIB HYDROCHLORIDE (P276-00);Riviciclib hydrochloride, 10 mM in DMSO;inhibit,Inhibitor,Riviciclib,CDK,Riviciclib hydrochloride,Cyclin dependent kinase,Apoptosis;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one:hydrochloride
CBNumber:
CB32668296
Molecular Formula:
C21H21Cl2NO5
Molecular Weight:
438.3
MOL File:
920113-03-7.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24
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P276 Properties

storage temp. Store at -20° C
solubility Soluble in DMSO
form Solid
color Off-white to light yellow

P276 Chemical Properties,Uses,Production

Uses

P276-00 is a cyclin-dependent kinase (CDK) inhibitor. P276-00 has shown to be highly selective for cancer cells and has shown to produce potent inhibition of Cdk4-D1 activity. P276-00 also induces apoptosis in human promyelocytic leukemia (HL-60) cells.

Enzyme inhibitor

This cell cycle-inhibiting flavone and anticancer agent (FW = 438.30 g/mol; CAS 920113-03-7), also named 2-(2-chlorophenyl)-5,7-dihydroxy-8- [(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4- one, targets the Cyclin-Dependent Kinases CDK1 (IC50 = 79 nM), CDK4 (IC50 = 63 nM) and CDK9 (IC50 = 20 nM). p276-00 showed potent antiproliferative effects against various human cancer cell lines (IC50 values ranging from 300 to 800 nmol/L), but has little effect on cultured fibroblasts. A significant down-regulation of cyclin D1 and Cdk4 and a decrease in Cdk4-specific pRb Ser(780) phosphorylation is observed. P276-00 produces potent inhibition of Cdk4-D1 activity that is competitive with ATP, and not with retinoblastoma protein. The compound also induced apoptosis in human promyelocytic leukemia (HL-60) cells, as evidenced by the induction of caspase-3 and DNA ladder studies. In 22 human cancer xenografts, P276-00 is approximately 26x more potent than cisplatin, and is also active against cisplatin-resistant tumors of central nervous system, melanoma, prostate, and renal cancers. Synchronized human non-small cell lung carcinoma (H-460) and human normal lung fibroblast (WI-38) cells are arrested in G1

P276 Preparation Products And Raw materials

Raw materials

920112-99-8 920113-01-5 cis-((2S,3R)-1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl)methanol ((2R,3S)-1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl)methanol 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE
P276-00 (free base) 2-Chlorobenzoyl chloride 2-Chlorobenzoic acid 1,3,5-Trimethoxybenzene
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Preparation Products

P276 Suppliers

Global( 63)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30231 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
Chemtour Biotech Co., Ltd +8617327281506 China 1521 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8467 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Chemtour Biotech Co., Ltd 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58

920113-03-7(P276)Related Search:

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4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-, hydrochloride (1:1) P276-00 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-, hydrochloride (1:1) 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one:hydrochloride 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride Riviciclib hydrochloride CS-996 Riviciclib HCl RIVICICLIB HYDROCHLORIDE (P276-00) P276 USP/EP/BP Riviciclib HCl (P276-00) inhibit,Inhibitor,Riviciclib,CDK,Riviciclib hydrochloride,Cyclin dependent kinase,Apoptosis Riviciclib hydrochloride, 10 mM in DMSO P276 920113-03-7 Inhibitors