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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >CDK inhibitors >P276

P276

P276 Structure
CAS No.
920113-03-7
Chemical Name:
P276
Synonyms
P276;CS-996;P276 USP/EP/BP;Riviciclib HCl;Riviciclib HCl (P276-00);Riviciclib hydrochloride;RIVICICLIB HYDROCHLORIDE (P276-00);inhibit,Inhibitor,Riviciclib,CDK,Riviciclib hydrochloride,Cyclin dependent kinase,Apoptosis;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one:hydrochloride;2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride
CBNumber:
CB32668296
Molecular Formula:
C21H21Cl2NO5
Molecular Weight:
438.3
MOL File:
920113-03-7.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06
Request For Quotation

P276 Properties

storage temp. Store at -20° C
solubility Soluble in DMSO
form Solid
color Off-white to light yellow

P276 Chemical Properties,Uses,Production

Uses

P276-00 is a cyclin-dependent kinase (CDK) inhibitor. P276-00 has shown to be highly selective for cancer cells and has shown to produce potent inhibition of Cdk4-D1 activity. P276-00 also induces apoptosis in human promyelocytic leukemia (HL-60) cells.

Enzyme inhibitor

This cell cycle-inhibiting flavone and anticancer agent (FW = 438.30 g/mol; CAS 920113-03-7), also named 2-(2-chlorophenyl)-5,7-dihydroxy-8- [(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4- one, targets the Cyclin-Dependent Kinases CDK1 (IC50 = 79 nM), CDK4 (IC50 = 63 nM) and CDK9 (IC50 = 20 nM). p276-00 showed potent antiproliferative effects against various human cancer cell lines (IC50 values ranging from 300 to 800 nmol/L), but has little effect on cultured fibroblasts. A significant down-regulation of cyclin D1 and Cdk4 and a decrease in Cdk4-specific pRb Ser(780) phosphorylation is observed. P276-00 produces potent inhibition of Cdk4-D1 activity that is competitive with ATP, and not with retinoblastoma protein. The compound also induced apoptosis in human promyelocytic leukemia (HL-60) cells, as evidenced by the induction of caspase-3 and DNA ladder studies. In 22 human cancer xenografts, P276-00 is approximately 26x more potent than cisplatin, and is also active against cisplatin-resistant tumors of central nervous system, melanoma, prostate, and renal cancers. Synchronized human non-small cell lung carcinoma (H-460) and human normal lung fibroblast (WI-38) cells are arrested in G1

P276 Preparation Products And Raw materials

Raw materials

920112-99-8 920113-01-5 cis-((2S,3R)-1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl)methanol ((2R,3S)-1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl)methanol 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE
P276-00 (free base) 2-Chlorobenzoyl chloride 2-Chlorobenzoic acid 1,3,5-Trimethoxybenzene
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Preparation Products

P276 Suppliers

Global( 60)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Chemtour Biotech Co., Ltd +8617327281506 China 1460 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Chemtour Biotech Co., Ltd 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

920113-03-7(P276)Related Search:

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P276 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-, hydrochloride (1:1) P276-00 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-, hydrochloride (1:1) 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one:hydrochloride 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride Riviciclib hydrochloride CS-996 Riviciclib HCl RIVICICLIB HYDROCHLORIDE (P276-00) P276 USP/EP/BP Riviciclib HCl (P276-00) inhibit,Inhibitor,Riviciclib,CDK,Riviciclib hydrochloride,Cyclin dependent kinase,Apoptosis 920113-03-7 Inhibitors