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Ribociclib

CAS No.: 1211441-98-3

Chemical Name:: Ribociclib

Synonyms: 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;LEE11;LEE01;CS-1001;Kisqali.;Ribociclib;LEE011, >=98%;Ribociclib-d8;Ribociclib base;LEE-011. LEE 011

CBNumber:: CB32677045

Molecular Formula:: C23H30N8O

Molecular Weight:: 434.54

MOL File:: 1211441-98-3.mol

Modify Date:: 2024/5/27 13:35:05

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Ribociclib Properties

Boiling point	730.8±70.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
vapor pressure	0-0Pa at 20-25℃
storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml)
pka	8.67±0.10(Predicted)
form	solid
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
LogP	-0.8-2.3 at 20℃ and pH4-11

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Ribociclib Chemical Properties,Uses,Production

Description

LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G₁-S phase transition, arresting the cell cycle in the G₁ phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC₅₀ = 306 nM in sensitive lines).

Characteristics

Class: serine/threonine protein kinase
Treatment: Breast cancer
Oral bioavailability = 66%
Elimination half-life = 32 h
Protein binding = 70%

Uses

LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.

Mechanism of action

Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo.

Clinical Use

Ribociclib was first approved in 2017 as the second CDK4/6 (cyclin-dependent kinase) inhibitor in combination with aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor-2 negative (HER2?) advanced or metastatic breast cancer. In 2018, its label was expanded to pre/perimenopausal women with HR+/HER2? advanced or metastatic breast cancer.

Ribociclib Preparation Products And Raw materials

Raw materials

Preparation Products

Ribociclib Suppliers

Global( 226)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Dr. Reddy's Laboratories Ltd	+91-4049002900 +91-4049002900	Hyderabad, India	165	58	Inquiry
CDYMAX	+91-9019317788 +91-9019317788	Bangalore, India	28	58	Inquiry
Vachichem	+91-9886704423 +91-9880599557	Karnataka, India	72	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry

Supplier	Advantage
Dr. Reddy's Laboratories Ltd	58
CDYMAX	58
Vachichem	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

What is Ribociclib?
Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cy....
Jul 27，2021

What is Ribociclib?
Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cy....
Jul 27，2021

Ribociclib Spectrum

Ribociclib(1211441-98-3)MS Ribociclib(1211441-98-3)¹HNMR

1211441-98-3(Ribociclib)Related Search:

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7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE 011 LEE 011 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE011, >=98% 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE LEE-011, Ribociclib 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]- Ribociclib 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidi Ribociclib Ribociclib USP/EP/BP Ribociclib Lee011 Powder LEE11 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyri LEE01 CS-1001 LEE 011; LEE-011;RIBOCICLIB;LEE011 Ribociclib-d8 LEE-011,Ribociclib,LEE011 Kisqali. LEE-011. LEE 011 LEE011; LEE-011. LEE 011; RIBOCICLIB; KISQALI. 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Cyclin dependent kinase,LEE 011,Ribociclib,inhibit,Inhibitor,LEE-011,CDK Ribociclib base 1211441-98-3 C23H30N8O Inhibitors