Ribociclib
![Ribociclib Structure](CAS/20150408/GIF/1211441-98-3.gif)
- CAS No.
- 1211441-98-3
- Chemical Name:
- Ribociclib
- Synonyms
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;LEE11;LEE01;CS-1001;Kisqali.;Ribociclib;LEE011, >=98%;Ribociclib-d8;Ribociclib base;LEE-011. LEE 011
- CBNumber:
- CB32677045
- Molecular Formula:
- C23H30N8O
- Molecular Weight:
- 434.54
- MOL File:
- 1211441-98-3.mol
- Modify Date:
- 2024/5/27 13:35:05
Boiling point | 730.8±70.0 °C(Predicted) |
---|---|
Density | 1.39±0.1 g/cm3(Predicted) |
vapor pressure | 0-0Pa at 20-25℃ |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 10 mg/ml) |
pka | 8.67±0.10(Predicted) |
form | solid |
color | Off-white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
LogP | -0.8-2.3 at 20℃ and pH4-11 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
Ribociclib Chemical Properties,Uses,Production
Description
LEE011 is a cyclin-
Characteristics
Class: serine/threonine protein kinase
Treatment: Breast cancer
Oral bioavailability = 66%
Elimination half-life = 32 h
Protein binding = 70%
Uses
LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
Mechanism of action
Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo.
Clinical Use
Ribociclib was first approved in 2017 as the second CDK4/6 (cyclin-dependent kinase) inhibitor in combination with aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor-2 negative (HER2?) advanced or metastatic breast cancer. In 2018, its label was expanded to pre/perimenopausal women with HR+/HER2? advanced or metastatic breast cancer.
Ribociclib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
CDYMAX | +91-9019317788 +91-9019317788 | Bangalore, India | 28 | 58 | Inquiry |
Vachichem | +91-9886704423 +91-9880599557 | Karnataka, India | 72 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Dr. Reddy's Laboratories Ltd | 58 |
CDYMAX | 58 |
Vachichem | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
SynZeal Research Pvt Ltd | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Hangzhou FandaChem Co.,Ltd. | 55 |
ATK CHEMICAL COMPANY LIMITED | 60 |
career henan chemical co | 58 |
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