Sivelestat sodium

CAS No.: 201677-61-4

Chemical Name:: Sivelestat sodium

Synonyms: Elaspol;Sivelestat sodium;Sivelestat(anhydrous);SIVELESTAT SODIUM HYDRATE;EI546 sodium tetrahydrate;ONO5046 sodium tetrahydrate;LY544349 sodium tetrahydrate;Sivelestat sodium Impurity A;SIVELESTAT SODIUM TETRAHYDRATE;Ono-EI-600 sodium tetrahydrate

CBNumber:: CB4679778

Molecular Formula:: C20H25N2NaO8S

Molecular Weight:: 476.48

MOL File:: 201677-61-4.mol

MSDS File:: SDS

Modify Date:: 2024/4/3 17:07:09

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Sivelestat sodium Properties

storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 20 mg/ml).
form	White solid.
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
CAS DataBase Reference	201677-61-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2935909099

Sivelestat sodium Chemical Properties,Uses,Production

Description

Sivelestat is an acyl enzyme inhibitor of neutrophil elastase, developed as an injectable formulation for the treatment of acute lung injury associated with systemic inflammatory response syndrome. A neutrophil predominant inflammation associated with excessive release of human neutrophil elastase (HNE) from azurophilic granules is capable of damaging both the lung parenchymal cells and the extracellular matrix allowing an alveolar capillary barrier disruption. Sivelestat is a sulfonanilide-containing pivaloyloxy benzene derivative prepared in a three step synthesis. This agent acts as a reversible and selective inhibitor of HNE with an lG.0 value of 0.044 PM. Sivelestat has exhibited potent protective effects against various causes of lung injuries in animal models. In an acid-induced acute lung injury model in conscious hamster, administration of sivelestat for 48 h following HCI instillation, dose-dependently reduced mortality and significantly improved the protein levels in bronchoalveolar lavage fluids and pulmonary artery pressure. In a similar study, the agent inhibited the endotoxin-induced acute lung dysfunctions (marked elevation of pulmonary vascular permeability, leukocyte migration, hemorrhage and parenchymal injury) in different animal species. Moreover, in a cardiopulmonary bypass model in dog, sivelestat ameliorated the respiratory index and interstitial-intra-alveolar edema. Sivelestat has a relatively poor bioavailability, due to an extensive first-pass metabolism and is easily hydrolyzed in vitro to an inactive metabolite. In two animal species, the half-life time was approximately 5-7 min. Clinical trials have shown that treatment with the agent improves respiratory function and facilitates early removal of patients from mechanical ventilation. However, in the last clinical study, conducted by Eli Lilly in patients with acute lung injury, no difference in mortality and safety was seen between sivelestat and placebo.

Uses

Treatment of acute lung injury; acute respiratory distress syndrome (elastase inhibitor).

Sivelestat sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Sivelestat sodium Suppliers

Global( 147)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
airuikechemical co., ltd.	+undefined86-15315557071	China	961	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Hebei Duling International Trade Co. LTD	+8617333973358	China	15440	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
Chemtour Biotech Co., Ltd	+8617327281506	China	1460	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
airuikechemical co., ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Hebei Duling International Trade Co. LTD	58
LEAP CHEM CO., LTD.	58
Chemtour Biotech Co., Ltd	58

Sivelestat sodium Spectrum

Sivelestat sodium(201677-61-4)¹HNMR

201677-61-4(Sivelestat sodium)Related Search:

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Glycine 4-Methoxyphenylacetone Trisodium phosphate Sodium chlorite Benzoyl chloride

ETHANE Sodium chloride Mesna Chlorodimethylphenylsilane N,N-Dimethylformamide

Diphenyldimethoxysilane Dimethyl carbonate Sivelestat

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SIVELESTAT SODIUM HYDRATE SIVELESTAT SODIUM TETRAHYDRATE n-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt tetrahydrate Sivelestat sodium N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-Glycine monosodium salt tetrahydrate Sivelestat(anhydrous) Glycine, N-[2-[[[4-(2,2-diMethyl-1-oxopropoxy)phenyl]sulfonyl]aMino]benzoyl]-, MonosodiuM salt, tetrahydrate sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate Sivelestat sodium Impurity A EI546 sodium tetrahydrate LY544349 sodium tetrahydrate ONO5046 sodium tetrahydrate LY 544349;ONO-5046;LY-544349;LY544349 Sivelestat sodium hydrate (ONO-5046 sodium hydrate) Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4) Elaspol Sodium 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetate tetrahydrate Ono-EI-600 sodium tetrahydrate N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy) phenyl]sulfonyl]amino]benzoyl]-(s)-glycine monosodium salt tetra hydrate 201677-61-4 C20H21N2O7SNa4H2O C20H21N2NaO7S C20H21N2NaO7S4H2O C20H29N2NaO11S