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Sivelestat

Sivelestat Structure
CAS No.
127373-66-4
Chemical Name:
Sivelestat
Synonyms
EI 546;CS-1329;ONO 5046;LY 544349;sivelestat;Sivelestate;Sivelestat RS;Sivelestat-d4;Sivelestat-d9;Sivelestate sodium
CBNumber:
CB0511469
Molecular Formula:
C20H22N2O7S
Molecular Weight:
434.46
MOL File:
127373-66-4.mol
MSDS File:
SDS
Modify Date:
2024/5/31 17:33:32
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Sivelestat Properties

Melting point 218-220°
Density 1.369±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: soluble10mg/mL, clear
form White to off-white solid
pka 3.67±0.10(Predicted)
color white to off-white
InChIKey BTGNGJJLZOIYID-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

WGK Germany  nwg

Sivelestat price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S7198 Sivelestat sodium salt hydrate ≥98% (HPLC), solid 127373-66-4 5MG ₹13130.73 2022-06-14 Buy
Sigma-Aldrich(India) S7198 Sivelestat sodium salt hydrate ≥98% (HPLC), solid 127373-66-4 25MG ₹52988.38 2022-06-14 Buy
Sigma-Aldrich(India) 324759 Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is prima 127373-66-4 1MG ₹11880.01 2022-06-14 Buy
Product number Packaging Price Buy
S7198 5MG ₹13130.73 Buy
S7198 25MG ₹52988.38 Buy
324759 1MG ₹11880.01 Buy

Sivelestat Chemical Properties,Uses,Production

Uses

Sivelestat is an inhibitor of neutrophil elastase that prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock. The inhibition of neutropil elastase by Sivelestat is a promising therapeutic strategy to inhibit glial scar and promote functional recovery by upregulating angiopoietin-1 after spinal cord injury.

General Description

A cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC50 = 5.6 μM) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.

Biochem/physiol Actions

Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.

Sivelestat Preparation Products And Raw materials

Raw materials

Preparation Products

Sivelestat Suppliers

Global( 112)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9322 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503259 +86-19930503259 China 18435 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
AFINE CHEMICALS LIMITED 58
Baoji Guokang Bio-Technology Co., Ltd. 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Hebei Guanlang Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

Sivelestat Spectrum

Sivelestat(127373-66-4)1HNMR

127373-66-4(Sivelestat)Related Search:

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Orlistat N,N-Dimethylformamide ALTRENOGEST Sulfuryl chloride Phenyl salicylate
N,N-Dimethyl-1,4-phenylenediamine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Oseltamivir phosphate ULINASTATIN Dimethyl fumarate
Diethoxydimethylsilane PHENYL VALERATE Oseltamivir
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EI 546 sodium salt hydrate Elaspol sodium salt hydrate LY 544349 sodium salt hydrate o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate Ono-5046 sodium salt hydrate Sivelestat sodium salt hydrate Sivelestat (ONO-5046) 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid n-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)glycine Sivelestate sodium Sivelestat(anhydrous, free acid) ONO 5046 2-[[2-[(4-pivaloyloxyphenyl)sulfonylamino]benzoyl]amino]acetic acid 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]phenyl]carbonylamino]ethanoic acid Sivelestate Glycine, N-[2-[[[4-(2,2-diMethyl-1-oxopropoxy)phenyl]sulfonyl]aMino]benzoyl]- Sivelestat SodiuM anhydrous, free acid 2-{[2-({4-[(2,2-diMethylpropanoyl)oxy]benzene}sulfonaMido)phenyl]forMaMido}acetic acid EI 546 LY 544349 Sivelestat sodium Impurity sivelestat (2-((4-(Pivaloyloxy)phenyl)sulfonamido)benzoyl)glycine Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem EI-546;LY-544349;ONO-5046 CS-1329 N-[2-{N'-(carboxy-methyl-)-amino-carbonyl-}-phenyl-]-4-t-butyl-carbonyl-oxy-benz-enesulfo-mide SIVELESTAT(ONO5046; LY544349; EI546) Sivelestat RS Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester Sivelestat-d4 Sivelestat-d9 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]aceticaci N-[2[[[4-(2,2-Dimethylpropanoyl)oxy]phenyl]sulfonyl)amino]benzoyl]glycine 127373-66-4