Orlistat
- CAS No.
- 96829-58-2
- Chemical Name:
- Orlistat
- Synonyms
- Orlistate;XENICAL;Orlistat Powder;aolisita;Orlipastat, Orlistat;N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER;(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER;Alisit;CS-836;oristat
- CBNumber:
- CB2431985
- Molecular Formula:
- C29H53NO5
- Molecular Weight:
- 495.73
- MOL File:
- 96829-58-2.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | <50 °C |
|---|---|
| Boiling point | 615.9±30.0 °C(Predicted) |
| alpha | D20 -32.0° (c = 1 in chloroform) |
| Density | 0.976±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 19 mg/mL |
| form | solid |
| pka | 14.59±0.23(Predicted) |
| color | white |
| Merck | 14,6869 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| InChIKey | AHLBNYSZXLDEJQ-FWEHEUNISA-N |
| SMILES | C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O |
| CAS DataBase Reference | 96829-58-2(CAS DataBase Reference) |
Orlistat price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O4139 | Orlistat ≥98%, solid | 96829-58-2 | 25MG | ₹13671.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1445 | Orlistat Pharmaceutical Secondary Standard; Certified Reference Material | 96829-58-2 | 1G | ₹14992.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O4139 | Orlistat ≥98%, solid | 96829-58-2 | 100MG | ₹54666.25 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0381 | Orlistat | 96829-58-2 | 100MG | ₹7900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | O0381 | Orlistat | 96829-58-2 | 1G | ₹34000 | 2022-05-26 | Buy |
Orlistat Chemical Properties,Uses,Production
Description
Orlistat was launched in the UK as Xenical for the long-term treatment of obesity, preferably in conjunction with a moderately reduced calorie diet. Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from Streptomyces toxyfncini) and can be obtained either by hydrogenation of lipstatine or by several different synthetic ways involving many steps from ( S ) - rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a result, it prevents the absorption of about one third of the fat contained in food and acts as an effective weight-reducing therapy. The outcomes of several clinical trials involving thousands of obese patients showed that Orlistat promotes a significant weight loss (often between 5 and 10% after one year) and improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio, blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic absorption, the majority of the compound itself being recovered in the feces ; it does not affect other gastrointestinal processes, or the absorption of other rnacronutrients such as carbohydrates and proteins.
Chemical Properties
Off-White Solid
Uses
Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.
Biological Activity
Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .
Orlistat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Divis Laboratories Ltd | +91-4066966413 +91-4066966413 | Hyderabad, India | 34 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| DIVIS LABORATORIES LTD | +91 (40) 6696 6300 | New Delhi, India | 38 | 58 | Inquiry |
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