Mesna
- CAS No.
- 19767-45-4
- Chemical Name:
- Mesna
- Synonyms
- SODIUM 2-MERCAPTOETHANESULFONATE;mesnaum;COENZYME M;SodiuM 2-Mercaptoethanesulfonate (Mesna);2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT;MESNA;MESNEX;mesnum;D 7093;Mesina
- CBNumber:
- CB7277461
- Molecular Formula:
- C2H7NaO3S2
- Molecular Weight:
- 166.18
- MOL File:
- 19767-45-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/16 15:32:52
| Melting point | >240°C dec. |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml). |
| Merck | 14,5909 |
| BRN | 3657828 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 19767-45-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | KI7968000 | |||||||||
| HS Code | 2930 90 98 | |||||||||
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock) | |||||||||
| NFPA 704 |
|
Mesna price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M1511 | Sodium 2-mercaptoethanesulfonate analytical standard, ≥98.0% (titration) | 19767-45-4 | 5G | ₹9396.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M1511 | Sodium 2-mercaptoethanesulfonate analytical standard, ≥98.0% (titration) | 19767-45-4 | 10G | ₹15555.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1570 | Mesna Pharmaceutical Secondary Standard; Certified Reference Material | 19767-45-4 | 500MG | ₹9201.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M1511 | Sodium 2-mercaptoethanesulfonate analytical standard, ≥98.0% (titration) | 19767-45-4 | 25G | ₹24572.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.10595 | Sodium 2-mercaptoethanesulfonate for synthesis | 19767-45-4 | 10G | ₹7890 | 2022-06-14 | Buy |
Mesna Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
World Health Organization (WHO)
Mesna, an antidote used to protect patients treated with cyclophosphamide or ifosfamide from haemorrhagic vesiculitis, was introduced on the market in 1984. Shortly afterwards, its use became associated with allergic reactions, which occurred mainly in patients treated with the oral solution. This led to the withdrawal of this formulation in Germany, the only country where it was marketed. An oral liquid dosage form is still registered, but not marketed, in the Netherlands and products for intravenous injection remain available elsewhere.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Contact allergens
Mesna is used as a mucolytic agent, and as an antidote to chloro-acetyl-aldehyde and acrolein (a bladder toxic metabolite of ifosfamide or cyclophosphamide). It hasbeen reported as a cause of occupational allergic (hand and airborne) dermatitis in nurses
Purification Methods
It can be recrystallised from H2O and does not melt below 250o. It is purified further by converting to the free acid by passing a 2M solution through an ion-exchange (Amberlite IR-120) column in the acid form, evaporating the eluate in a vacuum to give the acid as a viscous oil (readily decomposes) which can be checked by acid and SH titration. It is then dissolved in H2O, carefully neutralised with aqueous NaOH, evaporated and the salt recrystallised from H2O [Schramm J Am Chem Soc 77 6231 1955]. [Beilstein 4 IV 85.]
Mesna Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AARTI INDUSTRIES LIMITED | 912267976666 | New Delhi, India | 172 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Molecraft LifeSciences Pvt Ltd | +91 (91) 6018-8881 | New Delhi, India | 757 | 0 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Sequent Scientific Limited (Alivira Animal Health) | 91-22-41114777 | Maharashtra, India | 3 | 58 | Inquiry |
| Aadivighnesh Chem Private Ltd. | 91-22-28020015 | Maharashtra, India | 119 | 58 | Inquiry |
| KPS Chemicals & Pharmaceuticals | 91--8469484608 | Gujarat, India | 240 | 58 | Inquiry |