Tauroursodeoxycholic acid
- CAS No.
- 14605-22-2
- Chemical Name:
- Tauroursodeoxycholic acid
- Synonyms
- TUDCA;Taurolite;ursodeoxycholyltaurine;Tauroursodeoxycholic acid-D4;TUDCA Tauroursodeoxycholic Acid;tauroursodeoxycholic acid sodium;Tauroursodeoxycholic Acid (TUDCA);Tauroursodeoxycholic Acid-[d4] Sodium Salt;3a,7b-Dihydroxy-5b-cholan-24-oic Acid N-(2-Sulfoethyl)amide;ur906
- CBNumber:
- CB0404332
- Molecular Formula:
- C26H45NO6S
- Molecular Weight:
- 499.7
- MOL File:
- 14605-22-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/19 12:21:56
| Melting point | 173-175°C |
|---|---|
| Density | 1.216±0.06 g/cm3(Predicted) |
| refractive index | 46 ° (C=1, EtOH) |
| storage temp. | 15-25℃ |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming) |
| form | solid |
| pka | 1.42±0.50(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | BHTRKEVKTKCXOH-LBSADWJPSA-N |
| SMILES | [C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r| |
| CAS DataBase Reference | 14605-22-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 2 |
| RTECS | KI7372500 |
| HS Code | 29242990 |
| Toxicity | mouse,LD50,intravenous,350mg/kg (350mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #92-235918, |
Tauroursodeoxycholic acid price More Price(2)
Tauroursodeoxycholic acid Chemical Properties,Uses,Production
Description
Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.
Chemical Properties
Tauroursodeoxycholic acid is an off-White Solid. It is an ambiphilic bile acid. It is mainly found in black bear bile, which is the signature active ingredient in bear bile. It has antispasmodic, anticonvulsant, anti-inflammatory and gallstone dissolving effects.
Uses
Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile salt naturally occurring in the body. When bile salts reach the intestines, they can be metabolized by bacteria into ursodeoxycholic acid (UDCA). TUDCA is formed when taurine binds to UDCA. TUDCA is used to treat cholestasis, a condition in which bile fails to flow from the liver to the duodenum. TUDCA, UDCA, and other soluble bile salts can counteract the toxicity of regular bile acids when the latter are backed up in the liver. TUDCA is also used to treat cholesterol gallstones, dissolving them to a size in which they may be passed.
Definition
ChEBI: Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursoodeoxycholic acid. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. It derives from an ursodeoxycholic acid. It is a conjugate acid of a tauroursodeoxycholate.
Side effects
TUDCA is safe and well-tolerated in patients with liver transplants, liver cirrhosis, and other diseases, but no clinical data exist for treatments longer than 1 year.
There were no significant differences in adverse events between those receiving standard immunosuppressants versus those receiving bile acids in addition. Other trials in liver cirrhosis (up to 6 months) and ALS (1 year) have also reported that TUDCA is well-tolerated with diarrhea being the only side effect (Elia et al., 2016; Ma et al., 2016; Pan et al., 2013; Crosignani et al., 1996).
Tauroursodeoxycholic-Acid-Cognitive-Vitality-For-Researchers
Mode of action
Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursodeoxycholic acid. Bile acid is made by the liver and stored in the gallbladder and helps with digestion. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears, which is the signature active ingredient in bear bile. It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.
Tauroursodeoxycholic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VIVAN Life Sciences Pvt Ltd | +91-2225870080 +91-9987465183 | Maharashtra, India | 49 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Ami Lifesciences Pvt. Ltd | +91 265 232 3046 | Gujarat, India | 4 | 58 | Inquiry |
| Ralington Pharma | 91-79-48911722 | Gujarat, India | 312 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| AMI Drugs & Speciality Chemicals Private Limited | +91 0091 265 232 3046 | Gujarat, India | 74 | 58 | Inquiry |
| Hrishabh Life Sciences | 91-22-62215755 | Maharashtra, India | 158 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
Related articles
- Tauroursodeoxycholic Acid: Characteristics and Therapeutic Effect on Alzheimer's Disease
- Tauroursodeoxycholic acid shows promise for treating Alzheimer's by improving cognition via neuroprotective mechanisms, warran....
- Jul 2，2024
- Tauroursodeoxycholic Acid: Exploring its Vital Role in Various Biological Processes
- Tauroursodeoxycholic acid is a bile acid derived from ursodeoxycholic acid. It is naturally produced in the body through a ser....
- May 29，2023
- The bile acids——Tauroursodeoxycholic acid
- Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursoodeoxycholic acid. It has a role as a human metabo....
- Dec 31，2021
14605-22-2(Tauroursodeoxycholic acid)Related Search:
1of4
chevron_right