Sodium fluoride
- CAS No.
- 7681-49-4
- Chemical Name:
- Sodium fluoride
- Synonyms
- NaF;Sodium flouride;sodium floride;SODIUM FLUORIDE FOR ANALYSIS EMSURE ACS,ISO,REAG. PH EUR;氟钠化;gelii;Gleem;credo;Flura;Ossin
- CBNumber:
- CB8854278
- Molecular Formula:
- FNa
- Molecular Weight:
- 41.99
- MOL File:
- 7681-49-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 993 °C (lit.) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Boiling point | 1700 °C | ||||||||||||||
| Density | 1.02 g/mL at 20 °C | ||||||||||||||
| vapor pressure | 1.4 mm Hg ( 0 °C) | ||||||||||||||
| refractive index | 1.336 | ||||||||||||||
| Flash point | 1704°C | ||||||||||||||
| storage temp. | 2-8°C | ||||||||||||||
| solubility | H2O: 0.5 M at 20 °C, clear, colorless | ||||||||||||||
| form | powder | ||||||||||||||
| color | White to off-white | ||||||||||||||
| Specific Gravity | 2.558 | ||||||||||||||
| Odor | Odorless | ||||||||||||||
| PH | 7.0-10.0 (25℃, 0.5M in H2O) | ||||||||||||||
| Water Solubility | 4 g/100 mL (25 ºC) | ||||||||||||||
| Sensitive | Hygroscopic | ||||||||||||||
| Crystal Structure | NaCl type | ||||||||||||||
| crystal system | Cube | ||||||||||||||
| Merck | 14,8618 | ||||||||||||||
| Space group | Fm3m | ||||||||||||||
| Lattice constant |
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| Exposure limits |
ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3; TWA 2.5 mg/m3 |
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| Stability | Stable. Hydrolyzed by water. Reacts with mineral acids to generate highly toxic hydrogen fluoride. Incompatible with glass. | ||||||||||||||
| CAS DataBase Reference | 7681-49-4(CAS DataBase Reference) | ||||||||||||||
| NIST Chemistry Reference | Sodium fluoride(7681-49-4) | ||||||||||||||
| EPA Substance Registry System | Sodium fluoride (7681-49-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-32-36/38-22 | |||||||||
| Safety Statements | 23-24/25-45-36-22 | |||||||||
| RIDADR | UN 1690 6.1/PG 3 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 2.5 mg/m3 [*Note: The REL also applies to other inorganic, solid fluorides (as F).] | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | WB0350000 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Toxic/Hygroscopic | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2826 19 10 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| Hazardous Substances Data | 7681-49-4(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 0.18 g/kg (Smyth) | |||||||||
| NFPA 704 |
|
Sodium fluoride price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S6776 | Sodium fluoride BioReagent, suitable for insect cell culture, ≥99% | 7681-49-4 | 100G | ₹5163.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S6776 | Sodium fluoride BioReagent, suitable for insect cell culture, ≥99% | 7681-49-4 | 500G | ₹12557 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1408 | Sodium Fluoride Pharmaceutical Secondary Standard; Certified Reference Material | 7681-49-4 | 1G | ₹8162.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 77365 | Fluoride Standard for IC TraceCERT?, 1000?mg/L fluoride in water | 7681-49-4 | 100ML | ₹5629 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 67414 | Sodium fluoride 0.5 M solution | 7681-49-4 | 1ML | ₹6928 | 2022-06-14 | Buy |
Sodium fluoride Chemical Properties,Uses,Production
Description
Sodium fluoride, NaF, is a binary salt that is a clear, lustrous crystal or white powder. The insecticide grade is frequently dyed blue. It is soluble in water and has a specific gravity of 2.558, which is heavier than water. Sodium fluoride is highly toxic by ingestion and inhalation, and is also strongly irritating to tissue. The TLV is 2.5 mg/m3 of air. The four-digit UN identification number is 1690. The primary uses are fluoridation of municipal water at 1 ppm, as an insecticide, rodenticide, and fungicide, and in toothpastes and disinfectants.
Chemical Properties
Sodium fluoride is a white powder or colorless crystals. Often used in a solution. Odorless. Pesticide grade is often dyed blue.
Physical properties
Colorless cubic or tetragonal crystals; density 2.78 g/cm3; melts at 993°C; vaporizes at 1,695°C; moderately soluble in water 4.22 g/100mL at 18°C; soluble in hydrofluoric acid; insoluble in ethanol.
Uses
Sodium fluoride is a versatile chemical reagent widely used in the fields of chemical industry, medicine, food, materials and electrochemistry. It can be used as a reagent in analytical chemistry and biological experiments (such as protein and enzyme analysis); adding 1 ppm NaF to drinking water can be used to prevent dental caries. It is also used to make adhesives, disinfectants and dental products, or for pesticide formulation components; used as a food preservative, such as preservatives and anti-fermentation agents in alcohol distilleries; used as a component of ceramic enamel and flux, or to make coated paper and frosted glass; used to preserve animal specimens.
Preparation
Sodium fluoride is prepared by adding sodium hydroxide or sodium carbonate to a 40% solution of hydrofluoric acid. In excess hydrofluoric acid, sodium bifluoride, NaHF2 , is formed. NaF also is made by fusion of cryolite with caustic soda. Technical grade products are usually sold at 90 to 95% purity.
Definition
ChEBI: Sodium fluoride is a metal fluoride salt with a Na(+) counterion. It has a role as a mutagen.
General Description
Sodium fluoride is a colorless crystalline solid or white powder, or the solid dissolved in a liquid. Sodium fluoride is formed by the reaction of sodium carbonate and hydrofluoric acid. Sodium fluoride is soluble in water. Sodium fluoride is noncombustible. Sodium fluoride is corrosive to aluminum. Sodium fluoride is used as an insecticide. Sodium fluoride is also used to fluorinate water supplies, as a wood preservative, in cleaning compounds, manufacture of glass, and for many other uses.
Hazard
Toxic by ingestion and inhalation, strong irritant to tissue.
Health Hazard
Ingestion may cause vomiting, abdominal pain, diarrhea, convulsions, collapse, thirst, disturbed color vision, acute toxic nephritis.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Flammability and Explosibility
Fluorides are not combustible.
Industrial uses
Sodium fluoride is a white to yellowish powder, poorly soluble in water. The NaF solubility in water is 3.85% at 15 °C and 4.21% at 25 °C. Commercially, NaF is obtained by reacting hydrofluoric acid with sodium hydroxide. This reaction is a by-product during the production of superphosphates from fluoro-apatite. Sodium fluoride is an important depressant used exclusively during beneficiation of non-sulfide minerals, as well as the rare-earth minerals as a depressant alone or in combination with other depressants. It is used together with starch as co-depressant for rutile and ilmenite during zirconium– titanium separation or during reverse silicate flotation from rutile and ilmenite with cationic collectors. Although it is believed that Na2F is a silicate depressant, studies have shown that it does not depress silicate minerals. In fact, it improves depression of oxides and silicates when used with other depressants.
Clinical Use
Sodium fluoride (NaF) promotes the proliferation and activity of osteoblasts and is classified as a nonhormonal bone-forming agent. Because treatment with NaF induces bone formation, it is essential that this therapy be coupled with oral calcium supplementation (1,000 mg/day). Additionally, NaF exhibits moderate antiresorptive activity, because it inhibits osteoclastic activity when it is absorbed into the bone matrix. In the treatment of osteoporosis, the therapeutic window for this agent is fairly narrow: Doses less than 45 mg/day are subtherapeutic, and doses in excess of 75 mg/day impair bone mineralization. In addition, the bone that is formed in the presence of NaF is neither as well mineralized nor as strong as normal bone tissue. In fact, some
Safety Profile
Human poison by ingestion. Experimental poison by ingestion, skin contact, intravenous, intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects: changes in teeth and supporting structures, cyanosis, diarrhea, EKG changes, fluid intake, headache, hypermotihty, increased immune response, muscle weakness, musculo-skeletal changes, nausea or vomiting, paresthesia, ptosis (drooping of the eyelid from sympathetic innervation), respiratory depression, salivary gland changes, tremors. Experimental teratogenic and reproductive effects. Human mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental tumorigenic data. It is very phytotoxic. When heated to decomposition it emits toxic fumes of Fand NazO. Used in chemical cleaning, for fluoridation of drinking water, as a funglcide and insecticide. See also FLUORIDES
Potential Exposure
Widely used in the chemical industry; in water treatment and fluoridation of drinking water; as an insecticide, fungicide, and rodenticide; chemical cleaning; electroplating, glass manufacture; vitreous enamels; preservative for adhesives; toothpastes, disinfectant, dental prophylaxis; also used orally in the treatment of various bone diseases to increase bone density and to relieve bone pain.
Shipping
UN1690 Sodium fluoride, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise NaF from water by partial evaporation in a vacuum desiccator, or dissolve it in water, and precipitate ca half of it by adding EtOH. The precipitate is dried in an air oven at 130o for one day, and then stored in a desiccator over KOH. Its solubility in H2O is 4% at 15o and 4.3% at 25o. [Kwasnik in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 235 1963].
Incompatibilities
Contact with acids release toxic gas. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Sodium fluoride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| UNILOSA INTERNATINAL PRIVATE LIMITED | +91-9999069917 +91-9999069917 | New Delhi, India | 152 | 58 | Inquiry |
| oswal chemicals | +91-9173644055 +91-9173644055 | Gujarat, India | 66 | 58 | Inquiry |
| Kronox Lab Sciences Pvt Ltd | +91-9313231074 +91-9313231074 | Gujarat, India | 240 | 58 | Inquiry |
| Sujata Chemicals | +91-9898025496 +91-9898025496 | Gujarat, India | 73 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Jayfluoride PVT LTD | +91-8128987973 +91-6356977002 | Gujarat, India | 27 | 58 | Inquiry |
| Navin Fluorine International Ltd | +91-2266509999 +91-2266509999 | West Bengal, India | 7 | 58 | Inquiry |
| S B Chemicals | +91-9979887375 +91-9825146049 | Gujarat, India | 13 | 58 | Inquiry |
| Osrics Pharmachem Pvt Ltd (Suryansh Group) | +91-1722268435 +91-9876082829 | Punjab, India | 21 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| UNILOSA INTERNATINAL PRIVATE LIMITED | 58 |
| oswal chemicals | 58 |
| Kronox Lab Sciences Pvt Ltd | 58 |
| Sujata Chemicals | 58 |
| Merck Ltd | 58 |
| Jayfluoride PVT LTD | 58 |
| Navin Fluorine International Ltd | 58 |
| S B Chemicals | 58 |
| Osrics Pharmachem Pvt Ltd (Suryansh Group) | 58 |
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