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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Structure
CAS No.
493028-20-9
Chemical Name:
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
Synonyms
CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber:
CB0412427
Molecular Formula:
C12H14N2OS
Molecular Weight:
234.32
MOL File:
Mol file
Modify Date:
2023/9/4 16:42:00
Request For Quotation

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Properties

Boiling point 421.6±40.0 °C(Predicted)
Density 1.192±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
form Tan solid
pka 5.00±0.10(Predicted)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
HazardClass  IRRITANT

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties,Uses,Production

Description

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

Uses

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Suppliers

Global( 30)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 China 2992 58 Inquiry
Shanghai Haohong Scientific Co., Ltd. 400-400-8210725 China 39994 58 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24016 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Baoji Didu Pharmaceutical and Chemical Co., Ltd 029-61856358 15829046862 China 10011 58 Inquiry
Supplier Advantage
CHEMSWORTH 30
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Shanghai Haohong Scientific Co., Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Baoji Didu Pharmaceutical and Chemical Co., Ltd 58

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Spectrum

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE(493028-20-9)1HNMR
TIMTEC-BB SBB011699 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE CBFβ Inhibitor 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem CBFβ Inhibitor 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)- Runx1-CBFβ interaction inhibitor 1 493028-20-9