CI 15511
- CAS No.
- 131-28-2
- Chemical Name:
- CI 15511
- Synonyms
- NARCEIN;NARCEINE;CI 15511;NIH 10760;henyl)acetyl)-;CI 15511，Narceine;Narceine (base and/or unspecified salts);4-(methylenedioxy)phenyl)acetyl)-6-((6-(2-(dimethylamino)ethyl)-2-methoxy-;o-veratricacid,6-((6-(2-(dimethylamino)ethyl)-2-methoxy-3,4-(methylenedioxy)p;4-[2-(2-Hydroxy-1-naphtyl)-2-sodiosulfohydrazino]benzenesulfonic acid sodium salt
- CBNumber:
- CB0445649
- Molecular Formula:
- C23H27NO8
- Molecular Weight:
- 445.46
- MOL File:
- 131-28-2.mol
- Modify Date:
- 2023/5/4 17:34:32
| Melting point | 138°; mp 176° |
|---|---|
| Boiling point | 555.14°C (rough estimate) |
| Density | 1.3285 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| pka | pKb (20°) = 10.7, pKa = 9.3 |
| Water Solubility | 579.1mg/L(15 ºC) |
| CAS DataBase Reference | 131-28-2 |
CI 15511 Chemical Properties,Uses,Production
Description
An alkaloid of opium (Papaver somniferum) was first isolated by Pelletier in 1832 but not characterized until some years later by Couerbe and Anderson, the latter assigning to it the formula C23H2909N which was accepted until Freund showed that it contains H20 of crystallization. The base remains in the mother liquors after removal of the major alkaloids. It forms slender, colourless needles or prisms of the trihydrate, m.p. 170°C. It is optically inactive and dissolves readily in alkalies forming metallic derivatives. It behaves as a weak, monoacidic base forming well-crystallized salts. The hydrochloride crystallizes with 5.5 H20 from cold, dilute HCI, or as the trihydrate from hot solutions. From MeOH it yields crystals with 1 mole of solvent, m.p. 190-2°C. The aurichloride forms reddish-yellow needles, m.p. 130°C and the picrate has m.p. 195°C. With chlorine water, followed by the addition of ammonia, it gives a characteristic blood-red colour while with dilute iodine solution, the solid alkaloid develops a blue colour. With ethyl nitrite, narceine forms an oximino derivative which, on exhaustive methylation, furnishes trimethylamine, hemipinic acid and 2-cyano-3- methoxy-4: s-methylenedioxy-1-vinylbenzene.
Purification Methods
Recrystallise Narcein from water (as trihydrate). The styphnate has m 185-189o (from EtOH), and the picrate has m 200o (from EtOH). [Beilstein 19 H 370, 19 I 797, 19 II 386, 19 IV 4382.]
References
Couerbe., Annalen, 17,171 (1836)
Anderson., ibid, 86, 182 (1853)
Roser., ibid, 247, 167 (1888)
Freund, Frankforter., ibid, 277,20 (1893)
Freund, Oppenheimer., Ber., 42, 1084 (1909)
CI 15511 Preparation Products And Raw materials
Raw materials
Preparation Products
CI 15511 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| City Chemicals Corporation | 800-248-2436 | United States | 6462 | 72 | Inquiry |
| Research Plus, Inc. | 800 341-2296 (U.S. and Canada) | United States | 3676 | 51 | Inquiry |
| City Chemical LLC | 1-203-932-2489 | United States | 6710 | 72 | Inquiry |
| ChromaDex | 949 419 0288 | United States | 2501 | 76 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| HONEST JOY HOLDINGS LIMITED | +86-755-26404303 | United States | 6702 | 54 | Inquiry |
| CARBONE SCIENTIFIC CO.,LTD | +44(0)870 486 8629 | United Kingdom | 6682 | 30 | Inquiry |
| Leancare Ltd. | +33 962096793 | United Kingdom | 6460 | 42 | Inquiry |
| Carbosynth China Ltd. | +86 (512) 6260-5585 | China | 6538 | 50 | Inquiry |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | China | 3466 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| City Chemicals Corporation | 72 |
| Research Plus, Inc. | 51 |
| City Chemical LLC | 72 |
| ChromaDex | 76 |
| 3B Scientific Corporation | 47 |
| HONEST JOY HOLDINGS LIMITED | 54 |
| CARBONE SCIENTIFIC CO.,LTD | 30 |
| Leancare Ltd. | 42 |
| Carbosynth China Ltd. | 50 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 58 |
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