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4'-Hydroxy-3'-methoxypropiophenone

4'-Hydroxy-3'-methoxypropiophenone Structure
CAS No.
1835-14-9
Chemical Name:
4'-Hydroxy-3'-methoxypropiophenone
Synonyms
Propioguaiacone;PROPIOVANILLONE;Eugenol Impurity 21;4-HYDROXY-3-METHOXYPROPIOPHENONE;3-METHOXY-4-HYDROXYPROPIOPHENONE;4'-hydroxy-3'-methoxypropiophenone;Propiophenone, 4'-hydroxy-3'-methoxy;1-(4-hydroxy-3-methoxyphenyl)-1-propanone;1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-;1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE
CBNumber:
CB3205110
Molecular Formula:
C10H12O3
Molecular Weight:
180.2
MOL File:
1835-14-9.mol
MSDS File:
SDS
Modify Date:
2023/5/25 18:01:05
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4'-Hydroxy-3'-methoxypropiophenone Properties

Melting point 61-62 °C
Boiling point 180-185 °C(Press: 15 Torr)
Density 1.126±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.92±0.31(Predicted)
color White to Dark Beige
LogP 2.020 (est)
CAS DataBase Reference 1835-14-9(CAS DataBase Reference)
NIST Chemistry Reference 1-(4-hydroxy-3-methoxyphenyl)propanone(1835-14-9)
EPA Substance Registry System 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- (1835-14-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS09,GHS06
Signal word  Danger
Hazard statements  H411-H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes  T,N
Risk Statements  25-51/53
Safety Statements  45-61
HS Code  2914500090

4'-Hydroxy-3'-methoxypropiophenone Chemical Properties,Uses,Production

Uses

1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.

Preparation

Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)
with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;
with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)
with aluminium chloride in carbon disulfide
with titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)
with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)
with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001

4'-Hydroxy-3'-methoxypropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2-Chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one

4'-Hydroxy-3'-methoxypropiophenone Suppliers

Global( 98)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Biosyn Research Chemicals +91 9346022300/+91 9399339999 Telangana, India 1340 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
WinWin Chemical CO., Limited +86-0577-64498589 +8615325081899 China 14198 58 Inquiry
CD Chemical Group Limited +8615986615575 China 20356 58 Inquiry
Changzhou Anxuan Chemical Co., Ltd +86-0519-89882563 +86-18961279162 China 4226 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Biosyn Research Chemicals 58
Capot Chemical Co.,Ltd. 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
SIMAGCHEM CORP 58
WinWin Chemical CO., Limited 58
CD Chemical Group Limited 58
Changzhou Anxuan Chemical Co., Ltd 58

1835-14-9(4'-Hydroxy-3'-methoxypropiophenone)Related Search:

CHLOROPHOSPHONAZO III Citric acid monohydrate 1-Bromo-1-phenyl-2-propanone 2-CHLORO-3' 4'-DIMETHOXYBENZIL 97 CINOXACIN
Ethyl 3,4,5-trimethoxybenzoylacetate CI 15511 Propiophenone 5,6-Dimethoxy-1-indanone 3′,4′-(Methylenedioxy)propiophenone
4',6,7-Trimethoxyisoflavone Glycitein Cryptopine 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID Oxolinic acid
Methoxypropiophenone 4'-Hydroxypropiophenone Protopine
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3-METHOXY-4-HYDROXYPROPIOPHENONE 4-HYDROXY-3-METHOXYPROPIOPHENONE PROPIOVANILLONE 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone (propiovanillone) Propioguaiacone Propiophenone, 4'-hydroxy-3'-methoxy 1-(4-hydroxy-3-methoxyphenyl)-1-propanone 1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE Eugenol Impurity 21 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- 4'-hydroxy-3'-methoxypropiophenone 1835-14-9 Aromatic Propiophenones (substituted)