Oxolinic acid
- CAS No.
- 14698-29-4
- Chemical Name:
- Oxolinic acid
- Synonyms
- oxolinic;5-ETHYL-8-OXO-5,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLIC ACID;w4565;utibid;ossian;oxoboi;pietil;s-0208;uroxol;starner
- CBNumber:
- CB8177186
- Molecular Formula:
- C13H11NO5
- Molecular Weight:
- 261.23
- MOL File:
- 14698-29-4.mol
- Modify Date:
- 2024/5/27 15:57:40
| Melting point | 314-316°C (dec.) |
|---|---|
| Boiling point | 473℃ |
| Density | 1.3038 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point | >110°(230°F) |
| storage temp. | 2-8°C |
| solubility | Soluble in 0.5N NaOH with warming |
| form | Crystalline Powder |
| pka | 5.94±0.20(Predicted) |
| color | White |
| Water Solubility | 3.214mg/L(temperature not stated) |
| Sensitive | Light Sensitive |
| Merck | 13,7014 |
| BRN | 620635 |
| Stability | Stable. Combustible. |
| InChIKey | KYGZCKSPAKDVKC-UHFFFAOYSA-N |
| CAS DataBase Reference | 14698-29-4(CAS DataBase Reference) |
| EPA Substance Registry System | Oxolinic acid (14698-29-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25-60-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JI5075000 | |||||||||
| F | 10 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner) | |||||||||
| NFPA 704 |
|
Oxolinic acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O0877 | Oxolinic acid quinolone antibiotic | 14698-29-4 | 5G | ₹11712.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O0877 | Oxolinic acid quinolone antibiotic | 14698-29-4 | 25G | ₹44404.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 67126 | Oxolinic acid analytical standard | 14698-29-4 | 100MG | ₹5910.45 | 2022-06-14 | Buy |
| SRL | 91088 | Oxolinic Acid (OXO), 99% | 14698-29-4 | 5Gms | ₹8770 | 2022-05-26 | Buy |
| SRL | 91088 | Oxolinic Acid (OXO), 99% | 14698-29-4 | 25Gms | ₹32890 | 2022-05-26 | Buy |
Oxolinic acid Chemical Properties,Uses,Production
Description
Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-
Chemical Properties
Crystalline Solid
Uses
Oxolinic acid is a quinolone antibiotic used for studies on DNA winding and coiling and for studies on dopaminergic neurotransmission processes. It is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia
Definition
ChEBI: A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the tr atment of bacterial infections in cattle, pigs and poultry.
Antimicrobial activity
Like nalidixic acid, this drug is effective with respect to Gram-negative microorganisms and is used for the same indications. Synonyms of this drug are nidantin, prodoxol, ocolin, uroxol, and others.
General Description
Chemical structure: quinolone
Pharmaceutical Applications
An oral 4-quinolone with a tricyclic structure. Its antibacterial spectrum is very similar to that of nalidixic acid, but it is more active againstEnterobacteriaceae (MIC 0.25–2 mg/L). Grampositive bacteria, Ps. aeruginosa and anaerobes are resistant.
After repeated doses of 750 mg twice daily, mean plasma concentrations are initially very low, but steady state is reached at the third day and Cmax is around 3.5 mg/L. Administration with food delays absorption. Binding to plasma protein is about 80%. It undergoes complex biotransformation, and an enterohepatic cycle may account for the increase in the apparent elimination half-life from 4 to 15 h over 7 days of treatment as well as for the 20% of dose which can be recovered from the feces. About 50% of the dose appears in the urine in the first 24 h, partly in the form of metabolites, some of which display antibacterial activity.
Side effects common to the quinolones occur frequently. About one-quarter of patients treated with 750 mg every 12 h suffer nausea and vomiting or restlessness and insomnia. Its only use is in the treatment of lower urinary tract infections.
Safety Profile
Moderately toxic by ingestion. Low toxicity by skin contact. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Purify the acid by recrystallisation from aqueous Me2CO, 95% EtOH or dimethylformamide. It has UV 220, (255.5sh), max 259.5, 268, (298sh, 311sh), 321 and 326nm [ 14.8, (36.8sh), 38.4, 38.4, (6.4sh, 9.2sh), 10.8 and 11.2 x 103]. [Kaminsky & Mettzer J Med Chem 11 160 1968, Beilstein 17 H 6, 17 I 3, 17 II 202, 17 III/IV 13, 17/1 V 11.]
Oxolinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Rawia International HealthCare Pvt. Ltd. | 91-22-26425001 | Maharashtra, India | 170 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Cns Chemicals | 08066085913Ext 735 | Hyderabad, India | 262 | 58 | Inquiry |
| Esschem Pvt., Ltd. | 91-22-22182485 | Maharashtra, India | 96 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CNS CHEMICALS | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Reax Chemicals | 58 |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 58 |
| Rawia International HealthCare Pvt. Ltd. | 58 |
| Pharma Affiliates | 58 |
| Cns Chemicals | 58 |
| Esschem Pvt., Ltd. | 58 |
| HiMedia Laboratories | 58 |
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