4'-Hydroxypropiophenone
- CAS No.
- 70-70-2
- Chemical Name:
- 4'-Hydroxypropiophenone
- Synonyms
- PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat
- CBNumber:
- CB8854142
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MOL File:
- 70-70-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/30 19:23:35
| Melting point | 36-38 °C(lit.) |
|---|---|
| Boiling point | 152-154 °C26 mm Hg(lit.) |
| Density | 1.09 g/cm3 (20℃) |
| refractive index | 1.5360 (estimate) |
| FEMA | 2005 | ACETANISOLE |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | methanol: 0.1 g/mL, clear |
| form | Solid |
| pka | 8.87±0.26(Predicted) |
| color | White |
| Water Solubility | 0.34 g/l (15 ºC) |
| Merck | 14,7044 |
| BRN | 907511 |
| LogP | 2.030 |
| CAS DataBase Reference | 70-70-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2) |
| EPA Substance Registry System | 1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UH1925000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| Toxicity | LD50 orally in Rabbit: 11800 mg/kg | |||||||||
| NFPA 704 |
|
4'-Hydroxypropiophenone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H55405 | 4′-Hydroxypropiophenone 98% | 70-70-2 | 100G | ₹4319.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20692 | 4′-Hydroxypropiophenone for synthesis | 70-70-2 | 100G | ₹7229.99 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0299 | 4'-Hydroxypropiophenone min. 98.0 % | 70-70-2 | 25G | ₹1600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0299 | 4'-Hydroxypropiophenone min. 98.0 % | 70-70-2 | 500G | ₹7600 | 2022-05-26 | Buy |
| ALFA India | ALF-A15314-36 | 4'-Hydroxypropiophenone, 99% | 70-70-2 | 500g | ₹9215 | 2022-05-26 | Buy |
4'-Hydroxypropiophenone Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
Intermediates of Liquid Crystals
Preparation
Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).
Safety Profile
Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Purification Methods
4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]
4'-Hydroxypropiophenone Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| sheetalchemicals | +91-9820130159 +91-9820130159 | Maharashtra, India | 77 | 58 | Inquiry |
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| SHYAMAL LIFE SCIENCE PVT LTD | +91-9824420566 +91-9824420566 | Gujarat, India | 12 | 58 | Inquiry |
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| Swadev Chemicals | +91-9898998064 +91-7203031021 | Gujarat, India | 19 | 58 | Inquiry |
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| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| Earthchem Laboratories P Ltd | +91-9923536956 +91-9923536947 | Maharashtra, India | 59 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| sheetalchemicals | 58 |
| SANIKA CHEMICALS PVT.LTD. | 58 |
| SHYAMAL LIFE SCIENCE PVT LTD | 58 |
| Clarion Drugs Ltd | 58 |
| Swadev Chemicals | 58 |
| Pratap Organics Pvt Ltd | 58 |
| Jayco Chemical Industries | 58 |
| S D Fine Chem Limited | 58 |
| Earthchem Laboratories P Ltd | 58 |
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