2'-Hydroxypropiophenone
- CAS No.
- 610-99-1
- Chemical Name:
- 2'-Hydroxypropiophenone
- Synonyms
- 2-Propionylphenol;o-Propiophenol;2'-hydroxy acetone;o-Hydroxylpropioph;2'-Hydroxypropiophen;2-HYDROXYNITROBENZENE;O-HYDROXYPROPIOPHENONE;2-HYDROXYPROPIOPHENONE;2'-HYDROXYPROPIOPHENONE;o-Hydroxylpropiophenone
- CBNumber:
- CB5717338
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MOL File:
- 610-99-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/8 21:17:32
Melting point | 20-22 °C |
---|---|
Boiling point | 115 °C15 mm Hg(lit.) |
Density | 1.094 g/mL at 25 °C(lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Oil |
pka | 8.33±0.35(Predicted) |
color | Colourless |
BRN | 1860264 |
LogP | 2.540 |
CAS DataBase Reference | 610-99-1(CAS DataBase Reference) |
NIST Chemistry Reference | ortho-Hydroxypropiophenone(610-99-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29145090 | |||||||||
NFPA 704 |
|
2'-Hydroxypropiophenone price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H55103 | 2′-Hydroxypropiophenone 97% | 610-99-1 | 25G | ₹4790 | 2022-06-14 | Buy |
TCI Chemicals (India) | H0298 | 2'-Hydroxypropiophenone min. 97.0 % | 610-99-1 | 25G | ₹2800 | 2022-05-26 | Buy |
TCI Chemicals (India) | H0298 | 2'-Hydroxypropiophenone min. 97.0 % | 610-99-1 | 500G | ₹14100 | 2022-05-26 | Buy |
2'-Hydroxypropiophenone Chemical Properties,Uses,Production
Chemical Properties
CLEAR BROWNISH LIQUID
Preparation
Obtained by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ?, then at 130–150° for 2–3 h after solvent elimination (32–35%)
with aluminium chloride in chlorobenzene using microwave irradiation for 3 ? min at 106° (28%)
with aluminium chloride in nitrobenzene at 50° for 18 h (16%) or at ? 20° for 48 h (10%)
with aluminium chloride in nitromethane at 20° for 7 days (20%)
with aluminium chloride in heptane at 80–90° for 7 h (53%) or in tetrachlo-? roethane at 95° for 5 h (43%)
with aluminium chloride without solvent at 250° for 5 min or at 180–200° for ? 15 min (76–78%), at 140–160° (32–35%), at 140°
with zirconium chloride in o-dichlorobenzene at 120° for 3 h (83%)
with titanium tetrachloride in o-dichlorobenzene at 150° for 1 h (62%) ?, in nitromethane at 20° for 7 days (13%) or without solvent at 50° for 10 h (30%)
with titanium tetrabromide in o-dichlorobenzene at 150° for 1 h (60%)
with stannic chloride at 50° for 3 h (25%)
with boron trifluoride at 120–135° for 15 min (15%)
with zinc chloride at 180–200° for 15 min (10%)
with polyphosphoric acid at 100° (13%)
Also obtained by Friedel–Crafts acylation of phenol with propionyl chloride in the presence of aluminium chloride (40%), at 120–130° for 1 h (45%) according to the method
Also obtained by acylation of phenol with propionic acid
in the presence of boron trifluoride at 165° for 1 h (45%) or at 80° for ? 2 h (8%)
in the presence of polyphosphoric acid at 100° for 10 min (by-product)
in the presence of zinc chloride at 160° for 1 h
Also obtained by isomerization of 4-hydroxypropiophenone with aluminium chloride (1.5 equiv) at 165° for 1 h (40%) or at 180–200° for 15 min (55%)
Also obtained by demethylation of 2-propionylanisole with fuming hydrochloric acid (d = 1.19) in a sealed tube at 110° for 6 h
Also obtained (by-product) by heating 3-tert-butyl-4-hydroxypropiophenone with aluminium chloride at 170° for 15 min (13%)
Also obtained by treatment of 2,3-dimethylchromone with sodium ethoxide in boiling ethanol for 30 h according to the method
Also obtained from 2-allylphenol by treatment with perbenzoic acid in ethyl ether, first at 0°, then between 0° and 25° for 24 h (78%)
Also obtained by reaction of 2-bromophenyl propionate in a ethyl ether/hexane/THF mixture at low temperature (?78 to ?95°) with sec-butyllithium to give, after hydrolysis, the titled ketone (metal-promoted Fries rearrangement) (17%)
Also obtained by reaction of ethylmagnesium bromide
with 2-hydroxybenzamide in boiling benzene, followed by hydrolysis ? (30%)
with 2-hydroxy-N,N-diethylbenzamide in boiling benzene, followed by ? hydrolysis (82–84%)
Also isolated by heating of 1-(o-hydroxyphenyl)cyclopropyltrimethylam-monium iodide for 1 h at 140° with 1.5 equiv of N,N-diisopropylethylamine (not water-free) (38%)
Also obtained by hydrolysis of 2-(1-methyliminopropyl)phenol (4aa) with aqueous acetic acid/THF at 40° for 4 h (86%)
Also obtained by photolysis of phenyl propionate in water or in solution containing b-cyclodextrine (254 nm) at 25° for 2 h
Also obtained by treatment of 2-(1-hydroxypropyl)phenol with MnO2 in methylene chloride for 7 h at r.t.
2'-Hydroxypropiophenone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
Earthchem Laboratories P Ltd | +91-9923536956 +91-9923536947 | Maharashtra, India | 59 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
Earthchem Laboratories P. Ltd. | 91-9923536947 | Maharashtra, India | 37 | 58 | Inquiry |
Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
P C Chem | +91-8046061281 | Mumbai, India | 676 | 58 | Inquiry |
Supplier | Advantage |
---|---|
GLR Innovations | 58 |
Earthchem Laboratories P Ltd | 58 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
PEE ESS AROMATICS | 30 |
Earthchem Laboratories P. Ltd. | 58 |
Biosyn Research Chemicals | 58 |
A.J Chemicals | 58 |
SREE SYNERIC LAB | 58 |
Reax Chemicals | 58 |
P C Chem | 58 |
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