Phloretin
- CAS No.
- 60-82-2
- Chemical Name:
- Phloretin
- Synonyms
- Floretin;Phloretol;Dihydronaringenin;3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one;oretin;RJC 02792;PHLORETIN;Phloridin;Asebogenol;NSC 407292
- CBNumber:
- CB4161608
- Molecular Formula:
- C15H14O5
- Molecular Weight:
- 274.27
- MOL File:
- 60-82-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/5 12:01:54
| Melting point | ~260 °C |
|---|---|
| Boiling point | 337.26°C (rough estimate) |
| Density | 1.1827 (rough estimate) |
| FEMA | 4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE |
| refractive index | 1.573-1.575 |
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), Methanol (Slightly) |
| pka | 7.16±0.40(Predicted) |
| form | Powder |
| color | White to beige |
| Odor | odorless |
| Water Solubility | soluble |
| Merck | 14,7326 |
| JECFA Number | 2022 |
| BRN | 1887240 |
| InChIKey | VGEREEWJJVICBM-UHFFFAOYSA-N |
| LogP | 3.50 |
| CAS DataBase Reference | 60-82-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
Phloretin price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7912 | Phloretin ≥99% | 60-82-2 | 25MG | ₹7772.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7912 | Phloretin ≥99% | 60-82-2 | 100MG | ₹12253.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7912 | Phloretin ≥99% | 60-82-2 | 250MG | ₹24670.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 91897 | Phloretin analytical standard | 60-82-2 | 10MG | ₹7750.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 524488 | Phloretin - CAS 60-82-2 - Calbiochem A cell-permeable inhibtor of protein kinase C (IC?? = 20-50 μM). | 60-82-2 | 200MG | ₹15469.99 | 2022-06-14 | Buy |
Phloretin Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Phloretin has been used:
- to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake
- to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay
- as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro
Uses
As glucose transport inhibitor, Phloretin can inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.
Definition
ChEBI: Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a dihydrochalcone.
General Description
Phloretin is a dihydrochalcone flavonoid with antioxidant activity usually found in apples and apple-derived products. It is extensively used for peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.
Purification Methods
Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]
Phloretin Preparation Products And Raw materials
Global( 470)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD | 15202951039 | China | 268 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5832 | 58 | Inquiry |
| Bonerge(Hunan) Lifescience Co., Ltd. | +86-731-82791134 +86-18801900056 | China | 30 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
Related articles
- Uses of Phloretin
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- Oct 18，2022
60-82-2(Phloretin)Related Search:
2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone
Phloretin,98%
β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone
PHLORETIN(RG)
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-
trihydroxyphenyl)-
β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 2μ,4μ,6μ-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
2',4,4',6'-Tetrahydroxy-α,β-dihydro-trans-chalcone
Phloretin,β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Phloretin(Dihydronaringenin)
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
Asebogenol
NSC 407292
RJC 02792
Phloretin Synonyms 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
Phloretin
2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
PHLORETIN
PHLORETIN (NATURAL)
METHYL-4-4-(4-HYDROXYDIPHENYL METHYL)-PIPERIDINE-1-OXOBUTYL-2,2-DIMETHYLPHENYL ACETIC ACID.FEXOFENADINE INTERMEDIATE
2',4',6',4-TETRAHYDROXYDIHYDROCHALCONE
2,4,6-TRIHYDROXY-BETA-(4-HYDROXYPHENYL)PROPIOPHENONE
2',4',6'-TRIHYDROXY-3-P-HYDROXYPHENYLPROPIOPHENONE
2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-1-PROPIOPHENONE
2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-PROPIOPHENONE
BETA-(4-HYDROXYPHENYL)-2,4,6-TRIHYDROXY-PROPIOPHENONE
4,2',4',6'-TETRAHYDROXYDIHYDROCHALCONE
3-[4-HYDROXYPHENYL]-1-[2,4,6-TRIHYDROXYPHENYL]-1-PROPANONE
Phloridin
Water-Soluble Phloretin
Phloretin Nano-Liposome
oretin
Phloretin, 98.0+ % (HPLC)
Phloretin>
Phloretin 60-82-2
Phloretin - CAS 60-82-2 - Calbiochem
Phloretin 60-82-2 Natural Plant Extracts
factory Phloretin 60-82-2
Liposomal Phloretin,Water Soluble Phloretin,NanoActive Phloretin, Phloretin NanoEmulsion
Nanoactive Phloretin
Nano Liposomal Phloretin
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Dihydronaringenin
Floretin
Phloretol
Phloretin (6CI)
Icaritin Impurity 7
Phloretin (RJC 02792)
Dihydronaringenin|||NSC 407292|||RJC 02792
2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
60-82-2
80-82-2
60-82-8
1934-21-1
Voltage-gated Ion Channels
Organic Building Blocks
Inhibitors and Activators
Ion Channels