Phlorizin
- CAS No.
- 60-81-1
- Chemical Name:
- Phlorizin
- Synonyms
- NSC 2833;Floridzin;PHLORIZIN;Phlorinin;phlorhizin;phlorizine;PHLORIDZIN;phloridzine;phlorrhizin;Phlorrhizen
- CBNumber:
- CB0331801
- Molecular Formula:
- C21H24O10
- Molecular Weight:
- 436.41
- MOL File:
- 60-81-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/31 17:33:32
| Melting point | 113-114 °C(lit.) |
|---|---|
| Boiling point | 468.89°C (rough estimate) |
| Density | 1.3178 (rough estimate) |
| refractive index | -54 ° (C=3.2, 95% EtOH) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.15±0.40(Predicted) |
| color | Light Yellow to Tan |
| Merck | 14,7327 |
| InChIKey | IOUVKUPGCMBWBT-LKLLPNDVNA-N |
| SMILES | C(C1C(=CC(O)=CC=1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)(=O)CCC1C=CC(O)=CC=1 |&1:9,10,11,13,15,r| |
| LogP | 0.452 (est) |
| CAS DataBase Reference | 60-81-1(CAS DataBase Reference) |
| EPA Substance Registry System | Phlorizin (60-81-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UC2080000 | |||||||||
| F | 3-10-23 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Phlorizin Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Powder
Uses
Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.
Definition
ChEBI: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.
Purification Methods
-D-glucoside] [60-81-1] M 472.5, m 110o, [] 20 -62o (c 3.2, EtOH). Phlorizin crystallises as the dihydrate from water and causes glycosuria. [Brazy & Dennis Am J Physiol 234 1279 1978, Zemplen & Bognár Chem Ber 17B 1040 1943, Beilstein 17/7 V 177.]
Phlorizin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | China | 2605 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | China | 1003 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1143 | 58 | Inquiry |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | China | 939 | 58 | Inquiry |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 | China | 931 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
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