2',5'-DIHYDROXYPROPIOPHENONE
- CAS No.
- 938-46-5
- Chemical Name:
- 2',5'-DIHYDROXYPROPIOPHENONE
- Synonyms
- 2-PROPIONYLHYDROQUINONE;Methoxamine Impurity 22;2,5-DIHYDROXYPROPIOPHENONE;Methoxamine Impurity 11 HCl;2',5'-DIHYDROXYPROPIOPHENONE;2’,5’-dihydroxy-propiophenon;2',5'-DIHYDROXYPROPIOPHENONE;Propiophenone, 2',5'-dihydroxy-;2',5'-Dihydroxypropiophenone,98%;1-(2,5-DIHYDROXYPHENYL)PROPAN-1-ONE
- CBNumber:
- CB3395464
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MOL File:
- 938-46-5.mol
- Modify Date:
- 2022/12/30 16:20:48
| Melting point | 95-99 °C |
|---|---|
| Boiling point | 254.38°C (rough estimate) |
| Density | 1.1708 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| pka | 8.96±0.48(Predicted) |
| BRN | 1938824 |
| CAS DataBase Reference | 938-46-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| RTECS | UH0420000 | |||||||||
| HS Code | 2914310000 | |||||||||
| NFPA 704 |
|
2',5'-DIHYDROXYPROPIOPHENONE Chemical Properties,Uses,Production
Chemical Properties
yellowish crystalline powder
Preparation
Preparation by Fries rearrangement of quinol dipropionate (hydroquinone dipropionate),
with aluminium chloride without solvent at 130–140° for 4 h (75%), ? at 142° for 30 min (80%), at 160–165° for 3 h (good yields) or at 190–200° for 90 min (60%)
by using various quantities of aluminium chloride at 180° for 2 h (to see ? below)
with aluminium chloride (2 equiv) in nitromethane at 20° for a week (7%) ? or in nitrobenzene (24%)
with boron trifluoride complex (BF? 3-OBu2) at reflux for 1 h (42%)
by using titanium tetrachloride (2 equiv) at 130° for 2 h gave only 6% yield
Also obtained by treatment of
hydroquinone dipropionate with aluminium chloride in the presence of hyd-? roquinone (61%)
2-hydroxy-5-(propionyloxy)propiophenone with aluminium chloride (5 equiv) ? at 180° for 30 min in the presence of hydroquinone (57%)
Also obtained by acylation of hydroquinone with propionic acid
in the presence of boron trifluoride in ethylene dichloride at 50–55° (59%) ?, in tetrachloroethane at 90–95° for 5 h (70%) or at 50° for 4 h (70%) or without solvent (67%) at 80° for 2 h (54%) or at 125° for 2 h (71%)
in the presence of zinc chloride at 190° few min (Nencki reaction)
in the presence of 70% perchloric acid at reflux for 1 h (12%)
Also obtained by Friedel–Crafts acylation of hydroquinone with propionyl chlo-ride in nitrobenzene in the presence of aluminium chloride (40%)
Also obtained from 2-hydroxy-5-(propionyloxy)propiophenone; the ester group elimination on hydrolysis with 85% sulfuric acid at r.t. or by treatment with by aluminium chloride
Also obtained by reaction of benzoquinone (2.5 equiv) with 2-oxobutanoic acid in aqueous acetonitrile or an acetonitrile/methylene chloride mixture (91%).
2',5'-DIHYDROXYPROPIOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
2',5'-DIHYDROXYPROPIOPHENONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Biosyn Research Chemicals | +91-91-9346022300 +91-9346022300 | Telangana, India | 465 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| sgtlifesciences pvt ltd | +8617013299288 | China | 12382 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
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