3',4'-DIHYDROXYPROPIOPHENONE
- CAS No.
- 7451-98-1
- Chemical Name:
- 3',4'-DIHYDROXYPROPIOPHENONE
- Synonyms
- Dopamine Impurity;Erlotinib Impurity 124;3,4-DIHYDROXYPROPIOPHENONE;3',4'-DIHYDROXYPROPIOPHENONE;3’,4’-dihydroxy-propiophenon;3',4'-DIHYDROXYPROPIOPHENONE;3',4'-Dihydroxypropiophenone,98%;1-(3,4-dihydroxyphenyl)-1-propanon;1-(3,4-Dihydroxyphenyl)-1-propanone;1-(3,4-dihydroxyphenyl)propan-1-one
- CBNumber:
- CB4453934
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MOL File:
- 7451-98-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2022/12/21 16:56:50
| Melting point | 145-146°C |
|---|---|
| Boiling point | 375.1±27.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| pka | 8.75±0.31(Predicted) |
| CAS DataBase Reference | 7451-98-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| NFPA 704 |
|
3',4'-DIHYDROXYPROPIOPHENONE price More Price(2)
3',4'-DIHYDROXYPROPIOPHENONE Chemical Properties,Uses,Production
Uses
It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Preparation
Obtained by Fries rearrangement of pyrocatechol dipropio-nate with aluminium chloride in chlorobenzene at 80° for 2 h (84%) or in nitrobenzene at 100° for 15 min;
Obtained by Fries rearrangement of pyrocatechol dipropionate with aluminium chloride in the presence of pyrocatechol, in nitrobenzene at 80° for 1 h (37%) or in nitromethane at r.t. for 72 h (76%)
Also obtained by Fries rearrangement of o-methoxyphenyl propionate (1 mol) by aluminium chloride (2 mol) without solvent at 140° for 2 h (51–55%) or in nitrobenzene at 80° for 30–60 min. A demethylation occurs during the reaction.
Also obtained by acylation of pyrocatechol with propionic acid
in the presence of boron trifluoride, at 150° for 2 h in a sealed tube ? (36%)
in the presence of polyphosphoric acid for 15 min in a boiling water bath ? (12%)
Preparation by demethylation of 4-hydroxy-3-methoxypropiophenone with refluxing pyridinium chloride for 10 min (80%)
Also obtained when propiovanillone was heated with an alkali sulfide under conditions used in the kraft cooking process.
3',4'-DIHYDROXYPROPIOPHENONE Preparation Products And Raw materials
3',4'-DIHYDROXYPROPIOPHENONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10259 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15440 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Mainchem Co., Ltd. | +86-86-05926210733 +8618030271905 | China | 6572 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
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