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Protopine

Protopine Structure
CAS No.
130-86-9
Chemical Name:
Protopine
Synonyms
BIFLORIN;Protopin;PROTOPINE;Biflorine;Corydinine;Tangeratin;Hypercorine;AKOS 243-72;Corydalis C;Protopine USP/EP/BP
CBNumber:
CB9347526
Molecular Formula:
C20H19NO5
Molecular Weight:
353.37
MOL File:
130-86-9.mol
MSDS File:
SDS
Modify Date:
2023/7/12 16:34:12

Protopine Properties

Melting point 203-205?C
Boiling point 486.8°C (rough estimate)
Density 1.399 (calc)
refractive index 1.5800 (estimate)
storage temp. Inert atmosphere,2-8°C
Water Solubility Insoluble in water
solubility DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic)
pka 7.86±0.20(Predicted)
form powder to crystal
color White to Light gray to Light yellow
LogP 3.760 (est)
NIST Chemistry Reference Protopine(130-86-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
Safety Statements  24/25
RIDADR  1544
RTECS  VS2800000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29391900
Toxicity guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973.
NFPA 704
0
3 0

Protopine price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) P2611 Protopine min. 98.0 % 130-86-9 5MG ₹4400 2022-05-26 Buy
TCI Chemicals (India) P2611 Protopine min. 98.0 % 130-86-9 25MG ₹8800 2022-05-26 Buy
TCI Chemicals (India) P2611 Protopine min. 98.0 % 130-86-9 100MG ₹19800 2022-05-26 Buy
Product number Packaging Price Buy
P2611 5MG ₹4400 Buy
P2611 25MG ₹8800 Buy
P2611 100MG ₹19800 Buy

Protopine Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator

Definition

ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Purification Methods

It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]

Protopine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 189)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
SHANDONG ZHI SHANG CHEMICAL CO.LTD +86 18953170293 China 2931 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860 +86-18080483897 China 3424 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Neostar United (Changzhou) Industrial Co., Ltd. +86-519-519-85557386 China 11667 58 Inquiry
Apeloa Pharmaceutical Co., Ltd. +86-0571-87635730 +8615858229168 China 1478 58 Inquiry

Protopine Spectrum

7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)- 7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one Biflorine Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl- Corydinine Hypercorine Protopin BIFLORIN AKOS 243-72 5,7-DIHYDROXY-2-METHYLCHROMONE-6-C-BETA-D-GLUCOPYRANOSIDE PROTOPINE 4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c-5',6'-g] azecin-13(5H)-one 7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one 5-Methyl-9,10-(methylenedioxy)-4,6,7,13-tetrahydrobenzo[e]-1,3-dioxolo[4,5-l][2]benzazecine-12(5H)-one 6-Methyl-3,4-(methylenebisoxy)-10,11-(methylenebisoxy)-5,6,7,8-tetrahydrodibenzo[c,g]azecine-13(14H)-one 7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one 4,6,7,14-Tetrahydro-5-Methyl- Tangeratin Corydalis C Protopine (Corydinine) Protopine, 98%, from Corydalis yanhusuo W. T. Wang ex Z. Y. Su et C. Y. Wu Protopine USP/EP/BP 1H-Isoindole-1,3(2H)-dione,2-(3-butyn-2-yl)- 130-86-9 C20H19O5 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals