CINOXACIN
- CAS No.
- 28657-80-9
- Chemical Name:
- CINOXACIN
- Synonyms
- cinobac;Cinoxacin Solution in Methanol/DMSO, 1000μg/mL;1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid;CINOXACIN;Cinoxacino;Cinoxacinum;Compound 64716;Cinoxacin (200 mg);Cinoxacin (Cinobac;TIMTEC-BB SBB003082
- CBNumber:
- CB3200706
- Molecular Formula:
- C12H10N2O5
- Molecular Weight:
- 262.22
- MOL File:
- 28657-80-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:07
| Melting point | 261-262° (dec) |
|---|---|
| Boiling point | 405.47°C (rough estimate) |
| Density | 1.3545 (rough estimate) |
| refractive index | 1.6660 (estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: soluble50mg/mL |
| pka | pKa 5.38(H2O t=25.0 I=0.025) (Uncertain) |
| form | solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| CAS DataBase Reference | 28657-80-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 2 |
| RTECS | JI4640000 |
| Toxicity | LD50 in rats (mg/kg): 4160 orally; 900 i.v. (Narama) |
CINOXACIN price More Price(2)
CINOXACIN Chemical Properties,Uses,Production
Uses
Cinoxacin is an antibacterial quinolone previously known for its use in the treatment of urinary tract infections.
Definition
ChEBI: A member of the class of cinnolines that is 6,7-methylenedioxycinnolin-4(1H)-one bearing an ethyl group at position 1 and a carboxylic acid group at position 3. An analogue of oxolinic acid, it has similar antibacterial actions. It was formerly used for the treatment of urinary tract infections.
Antimicrobial activity
This drug is effective with respect to Gram-negative microorganisms and is used for the same indications as nalidixic and oxolinic acids. Synonyms of this drug are cinobactin, nossacin, uronorm, and others.
Pharmaceutical Applications
A cinnoline derivative formulated for oral administration. It is active against most Enterobacteriaceae, but Ps. aeruginosa, Gram-positive bacteria and anaerobes are resistant.
It is well-absorbed when given orally. Administration with food reduces the peak concentration by about one-third, but the area under the concentration–time curve (AUC) remains unchanged. Concentrations in prostatic and bladder tissues reach 60% and 80%, respectively, of the simultaneous serum concentrations.
It is almost entirely eliminated in the urine, about 40–60% as unchanged drug and the rest as metabolites, most of which have no antibacterial activity. Urinary concentrations of active drug in the first 2 h after administration of a dose is 100–500 mg/L. Elimination is reduced by probenecid and by renal impairment, the half-life rising to about 12 h in endstage renal failure.
Adverse reactions that are common to the group are reported in 4–5% of patients; these are primarily gastrointestinal tract disturbances, but rashes occur in up to 3% and CNS disturbances in less than 1%. Use is restricted to uncomplicated urinary tract infection.
Clinical Use
1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5g]cinnoline-3-carboxylic acid (Cinobac) is a close congener (isostere) ofoxolinic acid (no longer marketed in the United States) andhas antibacterial properties similar to those of nalidixic andoxolinic acids.
It is recommended for the treatment of urinary tract infectionscaused by strains of Gram-negative bacteria susceptibleto these agents. Early clinical studies indicate that thedrug possesses pharmacokinetic properties superior to thoseof either of its predecessors. Thus, following oral administration,higher urinary concentrations of cinoxacin thanof nalidixic acid or oxolinic acid are achieved. Cinoxacinappears to be more completely absorbed and less proteinbound than nalidixic acid.
CINOXACIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40067 | 58 | Inquiry |
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