MYXOTHIAZOL

CAS No.: 76706-55-3

Chemical Name:: MYXOTHIAZOL

Synonyms: Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-

CBNumber:: CB0453976

Molecular Formula:: C25H33N3O3S2

Molecular Weight:: 487.68

MOL File:: 76706-55-3.mol

Modify Date:: 2024/7/2 8:54:58

Request For Quotation

MYXOTHIAZOL Properties

Boiling point	679.6±65.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
form	Solid
pka	14.07±0.50(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264-P270-P301+P310-P405-P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	QH7580000
F	10
HazardClass	6.1(b)
PackingGroup	III

MYXOTHIAZOL price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T5580	Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC)	76706-55-3	1MG	₹11290.48	2022-06-14	Buy
Sigma-Aldrich(India)	T5580	Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC)	76706-55-3	5MG	₹45161.9	2022-06-14	Buy

Product number	Packaging	Price	Buy
T5580	1MG	₹11290.48	Buy
T5580	5MG	₹45161.9	Buy

MYXOTHIAZOL Chemical Properties,Uses,Production

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

MYXOTHIAZOL Preparation Products And Raw materials

Raw materials

Preparation Products

MYXOTHIAZOL Suppliers

Global( 24)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Chem-Impex International, Inc.	800 869-9290 US and Canada only	United States	6740	64	Inquiry
MP Biomedicals, Inc.	949 833 2500	United States	6566	81	Inquiry
Service Chemical Inc.	888-895-6920	Germany	6373	71	Inquiry
3B Scientific Corporation	847.281.9822	United States	6744	47	Inquiry
CHEMICAL LAND21	82- 2 -783 - 8063	South Korea	6315	74	Inquiry
CARBONE SCIENTIFIC CO.,LTD	+44(0)870 486 8629	United Kingdom	6682	30	Inquiry
SIGMA-RBI	800 736 3690 (Orders)	Switzerland	6913	91	Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	China	15848	69	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry
Guangdong wengjiang Chemical Reagent Co., Ltd.	0751-2815688 13927872512	China	10061	58	Inquiry

Supplier	Advantage
Chem-Impex International, Inc.	64
MP Biomedicals, Inc.	81
Service Chemical Inc.	71
3B Scientific Corporation	47
CHEMICAL LAND21	74
CARBONE SCIENTIFIC CO.,LTD	30
SIGMA-RBI	91
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Riedel-de Haen AG	87
Guangdong wengjiang Chemical Reagent Co., Ltd.	58

76706-55-3(MYXOTHIAZOL)Related Search:

2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL

2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL

4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL

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MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS MYXOTHIAZOL 5-dimethoxy-4-methyl- 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide myxothiazol from myxobacterium*myxococcus fulvus MYXOTHIAZOL, VIAL WITH 10 MG* MYXOTHIAZOL FROM MYXOBACTERIUM 95% myxothiazolfrommyxobacterium 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)- 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl- Myxothiazo 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)- 76706-55-3 C25H33N3O3S2 Antibiotics G-M Antibiotics Antibiotics A to Z BioChemical Inhibits an EnzymeNitric Oxide and Cell Stress Mitochondrial InhibitorsAntibiotics Antibiotics Antibiotics A to Antibiotics G-MAntibiotics AntifungalAntibiotics Cell Stress Chemical Structure Class Mechanism of Action Peptides Spectrum of Activity