ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Tryptophan derivatives >1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN

CAS No.: 110117-83-4

Chemical Name:: 1-METHYL-D-TRYPTOPHAN

Synonyms: Me-D-Trp;NLG-8189;IndoxiMod;1-Me-D-Trp;D-Trp(Me)-OH;H-D-Trp(1-Me)-OH;Indoximod (NLG-8189）;1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;D-Tryptophan, 1-methyl-

CBNumber:: CB0467553

Molecular Formula:: C12H14N2O2

Molecular Weight:: 218.25

MOL File:: 110117-83-4.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

1-METHYL-D-TRYPTOPHAN Properties

Melting point	242-245 °C(lit.)
alpha	12.4o (C = 2 IN ACETIC ACID)
Boiling point	429.3±35.0 °C(Predicted)
Density	1.28
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO (greater than 25 mg/ml).
pka	2.26±0.10(Predicted)
form	White to light brown crystalline powder.
color	White
optical activity	[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility	Soluble to 5 mM in water with gentle warming
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey	ZADWXFSZEAPBJS-SNVBAGLBSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

1-METHYL-D-TRYPTOPHAN price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	452483	1-Methyl-D-tryptophan 95%	110117-83-4	250MG	₹2706.25	2022-06-14	Buy
Sigma-Aldrich(India)	452483	1-Methyl-D-tryptophan 95%	110117-83-4	1G	₹8432.68	2022-06-14	Buy
Sigma-Aldrich(India)	452483	1-Methyl-D-tryptophan 95%	110117-83-4	10G	₹59970.5	2022-06-14	Buy

Product number	Packaging	Price	Buy
452483	250MG	₹2706.25	Buy
452483	1G	₹8432.68	Buy
452483	10G	₹59970.5	Buy

1-METHYL-D-TRYPTOPHAN Chemical Properties,Uses,Production

Description

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD⁺ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC₅₀ = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8⁺ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

Uses

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

1-METHYL-D-TRYPTOPHAN Preparation Products And Raw materials

Raw materials

Preparation Products

1-METHYL-D-TRYPTOPHAN Suppliers

Global( 197)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
MSN LABORATORIES PRIVATE LTD	+91 40 30438600	New Delhi, India	230	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	China	2995	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	China	13164	58	Inquiry

Supplier	Advantage
MSN LABORATORIES PRIVATE LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Xi'an Kono chem co., Ltd.,	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58

1-METHYL-D-TRYPTOPHAN Spectrum

1-METHYL-D-TRYPTOPHAN(110117-83-4)¹HNMR 1-METHYL-D-TRYPTOPHAN(110117-83-4)IR

110117-83-4(1-METHYL-D-TRYPTOPHAN)Related Search:

5-METHYL-DL-TRYPTOPHAN 1-METHYL-D-TRYPTOPHAN 1-METHYL-DL-TRYPTOPHAN Fmoc-D-Trp(Boc)-OH 1-METHYL-L-TRYPTOPHAN

5-METHYL-DL-TRYPTOPHAN HYDRATE α-Methyl-(S)-tryptophan,ALPHA-METHYL-L-TRYPTOPHAN 1-METHYL-L-TRYPTOPHAN D(+)-Tryptophan BOC-D-TPI(FOR)-OH

Z-D-TRP(BOC)-OH FMOC-D-TRP(ME)-OH H-D-TRP(BOC)-OH 7-METHOXY-1-METHYL-D-TRYPTOPHAN ETHYL ESTER BOC-D-TRP(FOR)-OH

H-D-TRP(FOR)-OH HCL BOC-N-ALPHA-METHYL-DL-TRYPTOPHAN 4-METHYL-DL-TRYPTOPHAN

chevron_left

1of4

chevron_right

1-METHYL-D-TRYPTOPHAN 1-Methyl-D-tryptophane 1-METHYL-D-TRYPTOPHAN 95% (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid IndoxiMod Indoximod (NLG-8189） NLG-8189 1-Me-D-Trp D-Trp(Me)-OH Me-D-Trp H-D-Trp(1-Me)-OH INDOXIMOD;1-METHYL-D-TRYPTOPHAN;1-METHYL-D-TRYPTOPHANE (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid D-Tryptophan, 1-methyl- 1-METHYL-D-TRYPTOPHAN USP/EP/BP (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid 110117-83-4 Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Tryptophan Inhibitors Amino Acid Derivatives Peptide Synthesis Tryptophan