1-METHYL-D-TRYPTOPHAN
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- ₹2706.25 - ₹59970.5
- Product name: 1-METHYL-D-TRYPTOPHAN
- CAS: 110117-83-4
- MF: C12H14N2O2
- MW: 218.25
- EINECS:
- MDL Number:MFCD00274271
- Synonyms:1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;IndoxiMod;Indoximod (NLG-8189）;NLG-8189;1-Me-D-Trp
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 250MG
- 1G
- 10G
- ManufacturerSigma-Aldrich(India)
- Product number452483
- Product description1-Methyl-D-tryptophan 95%
- Packaging250MG
- Price₹2706.25
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number452483
- Product description1-Methyl-D-tryptophan 95%
- Packaging1G
- Price₹8432.68
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number452483
- Product description1-Methyl-D-tryptophan 95%
- Packaging10G
- Price₹59970.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 452483 | 1-Methyl-D-tryptophan 95% | 250MG | ₹2706.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 452483 | 1-Methyl-D-tryptophan 95% | 1G | ₹8432.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 452483 | 1-Methyl-D-tryptophan 95% | 10G | ₹59970.5 | 2022-06-14 | Buy |
Properties
Melting point :242-245 °C(lit.)
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
Safety Information
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Description
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.Related product price
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