4-Chlorobenzil
- CAS No.
- 22711-23-5
- Chemical Name:
- 4-Chlorobenzil
- Synonyms
- 4-CHLOROBENZIL;Einecs 245-169-3;4-chlorodibenzoyl;4-Chlorobenzil, 98+%;(p-Chlorophenyl)phenylethanedione;Ethanedione,(4-chlorophenyl)phenyl-;Ethanedione, (4-chlorophenyl)phenyl-;2-(4-Chlorophenyl)-1-phenylethanedione;1-(4-Chlorophenyl)-2-phenylethan-1,2-dione;2-Phenyl-1-(4-chlorophenyl)-1,2-ethanedione
- CBNumber:
- CB0746966
- Molecular Formula:
- C14H9ClO2
- Molecular Weight:
- 244.67
- MOL File:
- 22711-23-5.mol
- Modify Date:
- 2023/9/26 17:18:59
| Melting point | 66-67°C |
|---|---|
| Boiling point | 163-165 °C(Press: 0.98 Torr) |
| Density | 1.272±0.06 g/cm3(Predicted) |
| InChI | InChI=1S/C14H9ClO2/c15-12-8-6-11(7-9-12)14(17)13(16)10-4-2-1-3-5-10/h1-9H |
| InChIKey | QDCKVAZDINMMHO-UHFFFAOYSA-N |
| SMILES | C(C1=CC=C(Cl)C=C1)(=O)C(C1=CC=CC=C1)=O |
| CAS DataBase Reference | 22711-23-5(CAS DataBase Reference) |
4-Chlorobenzil Chemical Properties,Uses,Production
Uses
Used as an intermediate in organic synthesis.
Synthesis
A benzene solution containing 51.2 g 4-chlorophenylacetic acid and 39.3 g thionyl chloride is refluxed for 6 hours and the solvent removed. The crude reaction product is added dropwise to a slurry of 40 g aluminum chloride in 200 ml benzene maintaining the temperature below 50° C. After addition the reaction is refluxed for 1.5 hours. After cooling, the mixture is poured into ice and the resulting white solid is separated yielding 61.3 g of crude product. The product is taken up in methylene chloride and washed with 5% sodium hydroxide solution followed by water, dried over sodium sulfate and stripped yielding 49.3 g (71%) of >95% pure 4'-chlorodeoxybenzoin. 15 g of 4-chlorodeoxybenzoin is dissolved in 105 ml pyridine. An aqueous solution containing 15 g potassium permanganate is added and the reaction stirred for 6 hours at room temperature using dry ice to buffer the pH near 7. The mixture is extracted with methylene chloride, the extract washed with water, dried over Na2SO4 and stripped. The residue is recrystallized from ethanol yielding 6.1 g of white plate-like crystals which is identified as starting material. Concentration of the mother liquor yields 4 g of 4-chlorobenzil.
4-Chlorobenzil Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chlorobenzil Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | China | 1227 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9626 | 58 | Inquiry |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | United States | 19639 | 58 | Inquiry |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | China | 8570 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| DSHare Pharmaceutical Science Technology Co.Ltd. | +8613962878782 | China | 42 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
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