ACRIDINE ORANGE
- CAS No.
- 65-61-2
- Chemical Name:
- ACRIDINE ORANGE
- Synonyms
- AO;AOX1;Lysotraker;CI NO 46005;BASIC ORANGE;-Cellstain-Ao;Euchrysine 3r;EUCHRYSINE 3RX;acridineoranger;RHODULINE ORANGE
- CBNumber:
- CB0747468
- Molecular Formula:
- C17H20ClN3
- Molecular Weight:
- 301.82
- MOL File:
- 65-61-2.mol
- Modify Date:
- 2024/3/26 18:04:44
Melting point | 284-287 °C(lit.) |
---|---|
Density | 1.001 g/mL at 20 °C |
refractive index | n20/D 1.338 |
storage temp. | -20°C |
solubility | Soluble in water, ethanol, dimethyl sulfoxide |
form | Powder |
pka | -3.2, 10.5(at 25℃) |
Colour Index | 46005 |
color | orange to red |
λmax | 500 nm |
BRN | 3734978 |
Biological Applications | Detecting cancer cells,spores,human papilloma virus (HPV),stress biomarkers; treating amyloid associated diseases,lupus,pathogen infections; apoptosis assays; cytotoxicity assays |
Major Application | Adhesives; aluminophosphate crystalline materials; detecting clay particles; display device; evaluating fiber surface characteristics; glass matrixes; imaging material; inks; lasers; recording materials; photoresists; textiles; thin films; tracers for hydrology; wiring boards |
CAS DataBase Reference | 65-61-2 |
EPA Substance Registry System | C.I. Basic Orange 14 (65-61-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H341 |
Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | AR7601000 |
HS Code | 32041300 |
Toxicity | dnd-mus:ast 20 mmol/L BBACAQ 374,96,74 |
ACRIDINE ORANGE price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 318337 | Acridine Orange hydrochloride hydrate ≥98% (HPLC) | 65-61-2 | 250MG | ₹2985.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A9231 | Acridine Orange solution 2% in H2O | 65-61-2 | 10ML | ₹13575.3 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 318337 | Acridine Orange hydrochloride hydrate ≥98% (HPLC) | 65-61-2 | 1G | ₹9024.3 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A8097 | Acridine Orange hydrochloride solution 10?mg/mL in H2O | 65-61-2 | 10ML | ₹10489.5 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 318337 | Acridine Orange hydrochloride hydrate ≥98% (HPLC) | 65-61-2 | 5G | ₹33300 | 2022-06-14 | Buy |
ACRIDINE ORANGE Chemical Properties,Uses,Production
Chemical Properties
dark orange to brown powder
Uses
Acridine orange is a dye that interacts with DNA and RNA by intercelation or electrostatic attraction. This cationic dye has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels.
Preparation
4,4 ‘-Bis (N, N-dimethyl) aminodiphenylmethane obtained dinitration of 4,4′ – bis (N, N-dimethyl) amino-2 ‘- dinitro-diphenyl methane reduction, and with an acid of heat, so that the diamino compound is cyclized product is oxidized and then cyclized and converted into zinc chloride double salt.
Safety Profile
Mutation data reported. Whenheated to decomposition it emits very toxic fumes of HCl,Cl??, and NOx.
Enzyme inhibitor
This cell-permeable dye (FWfree-base = 265.36 g/mol; CAS 65-61-2), also known as N,N,N',N'-tetramethylacridine-3,6-diamine, is an intercalator that binds tightly to nucleic acids. Binding to DNA is characterized by excitation maximum at 502 nm (cyan) and an emission maximum at 525 nm, producing a green fluorescence. (A 120 μM solution of acridine orange will detect 25-50 ng DNA per band in an agarose or polyacrylamide gel.) Binding to RNA is characterized by an excitation maximum at 460 nm and the emission maximum is located at 650 nm, yielding a reddish-orange fluorescence. Acridine orange also penetrates acidic compartments (e.g., lysosomes and phagolysosomes); upon protonation, the dye emits orange light when excited by blue light.
ACRIDINE ORANGE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Arnish Laborates Pvt Ltd | +91 7208475595 | Maharashtra, India | 187 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20293 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13341 | 58 | Inquiry |
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