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NECA

CAS No.: 35920-39-9

Chemical Name:: NECA

Synonyms: NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide;5'-N-Ethylcarboxamideadenosine

CBNumber:: CB0763077

Molecular Formula:: C12H16N6O4

Molecular Weight:: 308.29

MOL File:: 35920-39-9.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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NECA Properties

Melting point	229-231°C
Density	1.87±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka	12.93±0.70(Predicted)
form	powder
color	white
Stability	Hygroscopic
InChIKey	JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS DataBase Reference	35920-39-9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264-P270-P301+P310-P405-P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	22-26-36-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	VJ2232000
HazardClass	6.1(a)
PackingGroup	I
HS Code	29349990

NECA price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	E2387	5′-(N-Ethylcarboxamido)adenosine powder	35920-39-9	50MG	₹21747.43	2022-06-14	Buy
Sigma-Aldrich(India)	119140	Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem	35920-39-9	10MG	₹7430	2022-06-14	Buy

Product number	Packaging	Price	Buy
E2387	50MG	₹21747.43	Buy
119140	10MG	₹7430	Buy

NECA Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.

General Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1 μM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Biological Activity

Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

NECA Preparation Products And Raw materials

Raw materials

Preparation Products

NECA Suppliers

Global( 102)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26165	58	Inquiry
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	China	9980	58	Inquiry
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	China	4128	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
career henan chemical co	58
BOC Sciences	58
Dideu Industries Group Limited	58
NewCan Biotech Limited	58
Nanjing Doge Biomedical Technology Co., Ltd	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

NECA Spectrum

NECA(35920-39-9)¹HNMR

35920-39-9(NECA)Related Search:

he-neca 2-IODO-NECA 5'-EthylcarboxaMido-2',3'-isopropylidene Adenosine 2-Chloro-NECA NECA 5'-N-[ADENINE-2,8-3H]-

N6-BENZYL-NECA CGS 21680, [CARBOXYETHYL-3H(N)]- 2-CHLORO-2',3'-O-ISOPROPYLIDENEADENOSINE-5'-N-ETHYLCARBOXAMIDE EB-47 DIHYDROCHLORIDE DIHYDRATE CGS 21680

NECA 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE DANSYL-NECA 5'-N-ETHYLCARBOXAMIDOADENOSINE, [ADENINE-2,8-3H]- CGS-21680 HYDROCHLORIDE

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5'-N6-Ethylcarboxamidoadenosine 5'-ETHYLCARBOXAMIDOADENOSINE 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate 5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate 5’-n-ethylcarboxamidoadenosinehemihydrate adenosine-5’-(n-ethyl)carboxamidehemihydrate adenosine-5’-(n-ethylcarboxamide NECA b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl- D-NECA NECA,5′-(N-Ethylcarboxamido)adenosine Adenosine Receptor Agonist, NECA 5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE 1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide 5'-Ethylcarboxamido-D-adenosine 5'-N-Ethylcarboxamideadenosine 744-96 765-21 Adenosine-5'-ethylcarboxamide B-744-96 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide N-ethyl-5'-carboxamidoadenosine Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl- NECA USP/EP/BP 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide 5’-EthylcarboxamidoAdenosine 5'-N-Ethylcarboxamidoadenosine 5'-N-Ethylcarboxamidoadenosine (NECA) 35920-39-9 C12H16N6O4 Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors. Bases & Related Reagents Inhibitors Nucleotides Adenosine receptor