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METHYLERGONOVINE

METHYLERGONOVINE Structure
CAS No.
113-42-8
Chemical Name:
METHYLERGONOVINE
Synonyms
Partergin;Prestwick_727;Methylergometrin;Methylergobrevin;Methylergobasine;METHYLERGONOVINE;methylergometrine;Methylergonovine-D3;METHYLERGONOVINE USP/EP/BP;Methylergonovine (Methylergometrine)
CBNumber:
CB0833158
Molecular Formula:
C20H25N3O2
Molecular Weight:
339.44
MOL File:
113-42-8.mol
MSDS File:
SDS
Modify Date:
2023/5/4 17:34:31

METHYLERGONOVINE Properties

Melting point 172-173℃ (decomposition)
alpha D20 -45° (c = 0.4 in pyridine)
Boiling point 475.4°C (rough estimate)
Density 1.1492 (rough estimate)
refractive index 1.6650 (estimate)
storage temp. Desiccate at RT
pka pKa 6.65± 0.03(H2O,t =24,I<0.01)(Approximate)
color Prisms from MeOH/Me2CO

SAFETY

Risk and Safety Statements

Toxicity LD50 orl-rat: 93 mg/kg 27ZIAQ -,163,73

METHYLERGONOVINE Chemical Properties,Uses,Production

Chemical Properties

Shiny crystals; melts at 172°C (341.6°F);moderately soluble in water, dissolves readilyin alcohol and acetone.

Uses

Methylergonovine is a drug currently used as a smooth muscle constrictor during postpartum hemorrhage, as an inhibitor of the inflammasome complex in ASC-mediated procaspase-1 activation screening.

Health Hazard

The toxic effects due to methylergonovine inhumans include nausea, vomiting, dizziness,and hypertension. The oral and intravenousLD50 values in mice are 187 and 85 mg/kg,respectively.

Biological Activity

Active metabolite of methysergide ; uterotonic agent and oxytocic.

Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.

METHYLERGONOVINE Preparation Products And Raw materials

Global( 28)Suppliers
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9,10-Didehydo-N-[(S)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide Methylergobasine Methylergobrevin Methylergometrin Prestwick_727 [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamidemaleate N-[alpha-(Hydroxymethyl)propyl]-D-lysergamide Partergin METHYLERGONOVINE methylergometrine Ergoline-8-carboxaMide,9,10-didehydro-N-[(1S)-1-(hydroxyMethyl)propyl]-6-Methyl-, (8b)- Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8β)- Methylergonovine (Methylergometrine) METHYLERGONOVINE USP/EP/BP Methylergonovine-D3 113-42-8 104305-93-9 API