methysergide
- CAS No.
- 361-37-5
- Chemical Name:
- methysergide
- Synonyms
- C07199;UML-491;UML 491;Deseril;Desernyl;Methysergid;methysergide;Methylergometrine maleate EP Impurity G;9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8β-carboxamide;Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-
- CBNumber:
- CB9910759
- Molecular Formula:
- C21H27N3O2
- Molecular Weight:
- 353.46
- MOL File:
- 361-37-5.mol
- Modify Date:
- 2023/5/4 17:34:38
| Melting point | 194-196° |
|---|---|
| alpha | D20 -45° (c = 0.5 in pyridine) |
| Boiling point | 486.87°C (rough estimate) |
| Density | 1.1377 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | pKa 6.62± 0.02(H2O,t =24,I<0.01)(Approximate) |
| color | Off-White |
| Stability | Light Sensitive |
methysergide Chemical Properties,Uses,Production
Uses
Methysergide (Methylergonovine EP Impurity G) is a serotonergic receptor antagonist.
Clinical Use
Methysergide (Sansert), which is structurally identical to methylergonovine except for the addition of a methyl group to the indole nitrogen, has far less of the uterine stimulatory properties of the other agents and, instead, is used exclusively for treatment of migraine headache as a serotonin antagonist at 5-HT1/5-HT2 receptors.Methysergide is a potent peripheral inhibitor of 5-HT receptors in the blood vessel, which inhibits vessel-wall permeability. Methysergide also inhibits the release of histamine from mast cells and stabilizes platelets against the release of 5-HT, which may be responsible for the onset of the migraine attack. In contrast to its peripheral effects, methysergide appears to be a central 5-HT1 agonist, resulting in alleviation of the central hyperalgesia effect that occurs in patients with migraine.
methysergide Preparation Products And Raw materials
methysergide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| QUALITY CONTROL SOLUTIONS LTD. | 13670046396 | China | 18865 | 58 | Inquiry |
| Cdreamlab (Hubei) Technology Co., LTD | 0717-6300888 18062399888 | China | 297 | 58 | Inquiry |
| Shanghai New Union Textra Import & Export Co., Ltd | +861-348-227-9455 | China | 2752 | 60 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
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