Sumatriptan
- CAS No.
- 103628-46-2
- Chemical Name:
- Sumatriptan
- Synonyms
- gr43175;IMITREX;IMIGRAN;gr43175x;Sumatriptan;Imigran，Imitrex;SUMATRIPTAN BASE;SuMatriptan Maxalt;Sumatriptan (50 mg);Sumatriptan USP/EP/BP
- CBNumber:
- CB4135041
- Molecular Formula:
- C14H21N3O2S
- Molecular Weight:
- 295.4
- MOL File:
- 103628-46-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:03
| Melting point | 169-171°C |
|---|---|
| Boiling point | 497.7±55.0 °C(Predicted) |
| Density | 1.1778 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 9.5 (Uncertain) |
| color | Off-White to Pale Yellow |
| Water Solubility | 21.4 mg/mL |
| CAS DataBase Reference | 103628-46-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Sumatriptan(103628-46-2) |
| EPA Substance Registry System | 1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl- (103628-46-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361d-H412 |
| Precautionary statements | P202-P273-P280-P308+P313-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HS Code | 2935904000 |
Sumatriptan Chemical Properties,Uses,Production
Uses
Sumatriptan is a serotonin 5HT1-receptor agonist.
Definition
ChEBI: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor s btype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
General Description
Sumatriptan was the first triptan approved (1991) for theacute treatment of migraine headaches. It has the lowestoral bioavailability among all triptans because of its lowlipophilicity. The availability of many different dosageforms (i.e., an oral tablet, a SC injection, a nasal spray formulation,and a suppository) allows the flexibility of tailoringtherapy to the needs of the individual patients, thusmaking sumatriptans a very useful drug for an acute treatmentof migraine headaches. It also has a very fastonset of action via SC injection or nasal spray administration.However, sumatriptan is contraindicated withmonoamine oxidase inhibitors because it is primarily degradedby hepatic MAO-A. Thus, it may require frequentdosing as a result of its short duration of action to preventmigraine recurrence.
Sumatriptan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
| Dayaram Pharma Chem | +91-9601766800 +91-9601766800 | Gujarat, India | 61 | 58 | Inquiry |
| Synergene Active Ingredients Pvt. Ltd. | +91-04023700774 +91-04023700774 | Telangana, India | 96 | 58 | Inquiry |
| SMS Pharmaceuticals Ltd | +91-8179850881 +91-9100092121 | Telangana, India | 22 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Maithili Life Sciences Pvt Ltd | +91-9949816141 +91-9963263336 | Telangana, India | 33 | 58 | Inquiry |
| Niksan Pharmaceutical | +91-9537871777 +91-9537871777 | Gujarat, India | 39 | 58 | Inquiry |
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