Almotriptan

CAS No.: 154323-57-6

Chemical Name:: Almotriptan

Synonyms: LAS-31416;Almotriptan;LAS-31416-d6;ALMOTRIPTAN-D6;AlMotriptan API;ALMOTRIPTAN(SUBJECTTOPATENETFREE);1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine;N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine;1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine-d6;1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine

CBNumber:: CB7716603

Molecular Formula:: C17H25N3O2S

Molecular Weight:: 335.46

MOL File:: 154323-57-6.mol

Modify Date:: 2024/7/2 8:55:17

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Almotriptan Properties

Boiling point	538.7±60.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
pka	16.92±0.30(Predicted)
form	Solid
color	White to off-white
CAS DataBase Reference	154323-57-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Almotriptan Chemical Properties,Uses,Production

Description

Almotriptan was first marketed in Spain as a new medicine against acute attacks of migraine. It is the fifth agent belonging to the “triptan” class to be launched after sumatriptan, naratriptan, zolmitriptan and rizatriptan. This close structural analog of sumatriptan can be prepared in six steps from 4-nitrobenzylsulfonyl chloride with a Fischer indole synthesis as the key step. Almotriptan acts as a dual 5-HT_1D/1B agonist with a 35 to 51-fold selectivity versus 5-HT_1A and 5-HT₇ receptors respectively as well as having insignificant affinity for the most relevant nonserotonergic receptors (K1＞1μM). Its agonistic effect on 5-HT,n receptors of trigeminal sensory neurons turns off neurogenic inflammation by inhibiting the release of neuropeptides such as calcitonin gene-related peptide, neurokinin A and substance P. Concomitantly, its action on the 5-HT_1B receptors in meningeal arteries relieves the vasodilatation of these vessels associated with migraine attacks. Almotriptan causes selective concentration-dependent vasoconstriction of human meningeal and temporal arteries (with EC₅₀ of 0.03 and 0.7 μM) compared to basilar (EC₅₀ = 3.5 μM) and pulmonary arteries (EC₅₀＞10μM) or rabbit mesenteric and renal arteries (EC₅₀＞100 μM). Although it is predominantly cleared by the kidneys as unchanged drug (45%) or transformed into inactive metabolites by monoamine oxidase A (MAO-A) and CYP3A4 enzymes in the liver, almotriptan has the highest oral bioavailability (70%) of the triptans and has a half-life of 3.5 h. The therapeutic dose of 12.5 mg is well tolerated, shows a rapid onset of action (30 min) and low recurrence rate compared to sumatriptan.

Uses

Serotonin 5HT1B /1D-receptor agonist

Definition

ChEBI: An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position.

Almotriptan Preparation Products And Raw materials

Raw materials

COPPER(II) OXIDE Quinoline Pyrrolidine 1H-Indole-3-ethanol, 5-[(1-pyrrolidinylsulfonyl)methyl]- Butanal, 4-(dimethylamino)-, 2-[4-[(1-pyrrolidinylsulfonyl)methyl]phenyl]hydrazone

5-BROMO-N,N-DIMETHYLTRYPTAMINE DidesMethyl AlMotriptan {3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-yl}Methanol 5-CHLORO-N,N-DIMETHYLTRYPTAMINE Pyrrolidine, 1-(methylsulfonyl)- (9CI)

2-(5-IODO-1H-INDOL-3-YL)-N,N-DIMETHYLETHANAMINE Dimethylamine Formaldehyde

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Preparation Products

Almotriptan Suppliers

Global( 107)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Venkatasai Life Sciences	+91-9908134868 +91-8008303069	Hyderabad, India	186	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Calidad Pharma Chemie	08433672794	Mumbai, India	38	58	Inquiry
SMILAX LABORATORIES LIMITED	+91-40-23090260	New Delhi, India	6	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry

Supplier	Advantage
Venkatasai Life Sciences	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Calidad Pharma Chemie	58
SMILAX LABORATORIES LIMITED	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

Almotriptan Spectrum

Almotriptan(154323-57-6)¹HNMR

154323-57-6(Almotriptan)Related Search:

Minocycline Dimethyl carbonate Eletriptan hydrobromide Amorolfine Rizatriptan

Zolmitriptan Sumatriptan 1,3-Bis(aminomethyl)benzene ETHANE Dimethyl ether

N,N-Dimethylformamide Dimethyl fumarate Dimethyl sulfide Dacthal Eletriptan

Dimethylamine hydrochloride Dimethyl sulfoxide Dimethylamine

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LAS-31416-d6 ALMOTRIPTAN(SUBJECTTOPATENETFREE) Almotriptan N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine dimethyl-[2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethyl]amine AlMotriptan API N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine ALMOTRIPTAN-D6 1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine 1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine LAS-31416 1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine-d6 1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine-d6 1H-Indole-3-ethanamine, N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]- AlmotriptanQ: What is Almotriptan Q: What is the CAS Number of Almotriptan Q: What is the storage condition of Almotriptan Q: What are the applications of Almotriptan 154323-57-6 C17H19D6N3O2S Intermediates & Fine Chemicals Isotope Labeled Compounds Pharmaceuticals APIs Isotope Labelled Compounds Heterocyclic Compounds