Dantrolene
- CAS No.
- 7261-97-4
- Chemical Name:
- Dantrolene
- Synonyms
- C06939;DANTRILENE;Dantrolene (200 mg);Dantrolene (1163140);1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione;1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE;1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione;1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione;1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione;2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
- CBNumber:
- CB0875659
- Molecular Formula:
- C14H10N4O5
- Molecular Weight:
- 314.25
- MOL File:
- 7261-97-4.mol
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | 279-280° |
|---|---|
| Boiling point | 453.94°C (rough estimate) |
| Density | 1.3452 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Sonicated) |
| pka | 7.68±0.10(Predicted) |
| form | Solid |
| color | Yellow to Dark Yellow |
| Stability | Hygroscopic |
| EPA Substance Registry System | Dantrolene (7261-97-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H336 |
| Precautionary statements | P261-P271-P304+P340+P312-P403+P233-P405-P501 |
| HS Code | 2934990002 |
Dantrolene Chemical Properties,Uses,Production
Uses
Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.
Definition
ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
General Description
Crystals (in aqueous DMF).
Air & Water Reactions
Slightly water soluble. Dantrolene may be sensitive to heat and air .
Reactivity Profile
A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.
Fire Hazard
Flash point data for Dantrolene are not available. Dantrolene is probably combustible.
Dantrolene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SETV ASRV LLP | +91-9731133411 +91-9731133411 | Telangana, India | 531 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| sgtlifesciences pvt ltd | +8617013299288 | China | 12382 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 15026420323 | China | 49242 | 58 | Inquiry |