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2-Iodobenzoic acid

2-Iodobenzoic acid Structure
CAS No.
88-67-5
Chemical Name:
2-Iodobenzoic acid
Synonyms
O-IODOBENZOIC ACID;2-IODO BENZONIC ACID;NSC 3772;usafek-572;USAF ek-572;'LGC' (4009);O-iodine acid;IodobenzoicAcid;2-lodhenxoieacid;2-iodo-benzoicaci
CBNumber:
CB1126640
Molecular Formula:
C7H5IO2
Molecular Weight:
248.02
MOL File:
88-67-5.mol
MSDS File:
SDS
Modify Date:
2024/7/25 20:04:51

2-Iodobenzoic acid Properties

Melting point 160-162 °C(lit.)
Boiling point 313.9±25.0 °C(Predicted)
Density 2.25
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in dimethyl sulfoxide and methanol
pka 2.85(at 25℃)
form Powder, Crystals or Flakes
color Light yellow to orange-brown
Water Solubility sparingly soluble
Sensitive Light Sensitive
Merck 14,5030
BRN 1861406
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey CJNZAXGUTKBIHP-UHFFFAOYSA-N
CAS DataBase Reference 88-67-5(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 2-iodo-(88-67-5)
EPA Substance Registry System Benzoic acid, 2-iodo- (88-67-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38-20/21/22
Safety Statements  26-39-24/25-22-36
WGK Germany  3
RTECS  DH2975000
Hazard Note  Irritant
TSCA  T
HazardClass  IRRITANT, LIGHT SENSITIVE
HS Code  29163900
NFPA 704
1
2 0

2-Iodobenzoic acid price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) I7675 2-Iodobenzoic acid 98% 88-67-5 25G ₹1948.5 2022-06-14 Buy
Sigma-Aldrich(India) I7675 2-Iodobenzoic acid 98% 88-67-5 100G ₹4719.7 2022-06-14 Buy
TCI Chemicals (India) I0053 2-Iodobenzoic Acid min. 98.0 % 88-67-5 25G ₹2400 2022-05-26 Buy
TCI Chemicals (India) I0053 2-Iodobenzoic Acid min. 98.0 % 88-67-5 100G ₹3700 2022-05-26 Buy
TCI Chemicals (India) I0053 2-Iodobenzoic Acid min. 98.0 % 88-67-5 500G ₹15800 2022-05-26 Buy
Product number Packaging Price Buy
I7675 25G ₹1948.5 Buy
I7675 100G ₹4719.7 Buy
I0053 25G ₹2400 Buy
I0053 100G ₹3700 Buy
I0053 500G ₹15800 Buy

2-Iodobenzoic acid Chemical Properties,Uses,Production

Description

2-iodobenzoic acid and its derivatives are important pharmaceutical and chemical raw materials, which are necessary for the synthesis of various high-iodine reagents. It is commonly used as a precursor for the synthesis of 2-Iodoxybenzoic acid (IBX) and Dess-Martin peridinane, which are used as mild oxidants. It is also used in Suziki reaction.

Chemical Properties

white crystal powder. Soluble in alcohol and ether, insoluble in water.

Uses

Reagent for detection of sulfhydryl groups in proteins. 2-Iodobenzoic acid acts as a precursor in the preparation of 2-Iodoxybenzoic acid (IBX) and Dess-Martin periodinane, which finds application as an oxidizing agent in synthetic chemistry. It is also used in Suzuki reaction.

Preparation

2-Iodobenzoic acid is obtained from Anthranilic acid by diazotization and substitution. Diazotization of Anthranilic acid with sodium nitrite in the presence of sulfuric acid, control the temperature below 10℃, filter the diazotization solution, add the mixture of potassium iodide and sulfuric acid, stir for 10min after addition, and boil. Filter, wash with sodium thiosulfate solution, 2-Iodobenzoic acid can be recrystallized from water.

Definition

ChEBI: An iodobenzoic acid with a single iodo substituent placed at the 2-position.

Purification Methods

Crystallise the acid repeatedly from water and EtOH. Sublime it under vacuum at 100o. [Beilstein 9 IV 1030.]

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