ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Proline derivatives > N-Methyl-L-proline

N-Methyl-L-proline

CAS No.: 475-11-6

Chemical Name:: N-Methyl-L-proline

Synonyms: N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O

CBNumber:: CB1179181

Molecular Formula:: C6H11NO2

Molecular Weight:: 129.16

MOL File:: 475-11-6.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 15:51:00

Request For Quotation

N-Methyl-L-proline Properties

Melting point	114-116 °C(lit.)
Boiling point	227℃
Density	1.153
Flash point	91.1℃
refractive index	1.5000
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	2.37±0.20(Predicted)
form	Powder
color	White to off-white
Water Solubility	Soluble in water and methanol(both 50 mg/ml-clear-colorless solution)
InChI	InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey	CWLQUGTUXBXTLF-YFKPBYRVSA-N
SMILES	C(O)(=O)[C@@H]1CCCN1C
CAS DataBase Reference	475-11-6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

WGK Germany

HazardClass

IRRITANT

NFPA 704

	0
0		0

N-Methyl-L-proline price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M8021	N-Methyl-L-proline	475-11-6	500MG	₹42563.9	2022-06-14	Buy
Sigma-Aldrich(India)	M8021	N-Methyl-L-proline	475-11-6	1G	₹70914.58	2022-06-14	Buy

Product number	Packaging	Price	Buy
M8021	500MG	₹42563.9	Buy
M8021	1G	₹70914.58	Buy

N-Methyl-L-proline Chemical Properties,Uses,Production

Uses

N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.

Definition

ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.

Synthesis

L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.
N-Methyl-L-proline synthesis

N-Methyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-L-proline Suppliers

Global( 142)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	China	12962	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12459	58	Inquiry
Honest Joy Holdings Limited	0755-36694831 +8613717124449	China	300	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26216	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CHEMSWORTH	30
Alpha Biopharmaceuticals Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Honest Joy Holdings Limited	58
Dideu Industries Group Limited	58
BOC Sciences	58

N-Methyl-L-proline Spectrum

N-Methyl-L-proline(475-11-6)MS N-Methyl-L-proline(475-11-6)¹HNMR

475-11-6( N-Methyl-L-proline)Related Search:

N-METHYL-L-PROLINE MONOHYDRATE 98 N-Methyl-L-proline N-Cbz-Hydroxy-L-proline L-Alanyl-L-proline BOC-HYP(BZL)-OH

BOC-L-Proline N-(2,4-DINITROPHENYL)-L-PROLINE Fmoc-Pro-OH GLYCYL-L-PROLINE 4-METHOXY-2-METHYLBENZOIC ACID

(S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER L-Proline H-ALA-PRO-OME HCL Z-ALA-PRO-OH PHE-PRO

H-PRO-PRO-OH HCL H-MET-PRO-OH H-VAL-PRO-OTBU HCL

chevron_left

1of4

chevron_right

N-ME-L-PROLINE HYDROCHLORIDE N-ME-PROLINE N-ME-PRO-OH HCL N-METHYL-L-PROLINE MONOHYDRATE PYRD(2)-OH H2O N-ALPHA-METHYL-L-PROLINE N-ALPHA-METHYL-L-PROLINE HYDRATE N-ALPHA-METHYL-L-PYRROLIDINE-2-CARBOXYLIC ACID HYDRATE MEPYRD(2)-OH H2O H-MEPRO-OH H2O 1-Methylproline Hygric acid (2S)-1-Methylpyrrolidine-2-carboxylic acid (-)-Hygrinic acid (2S)-1-Methyl-2-pyrrolidinecarboxylic acid Hygrinic acid tert-butyl N-[4-(aminomethyl)cyclohexyl]carbamate,hydrochloride N-Me-L-Pro-OH N-Methyl-L-proline98+% N-METHYL-L-PROLINE MONOHYDRATE HCL L-Proline, 1-methyl- N-METHYL-L-PROLINE MONOHYDRATE USP/EP/BP N-Methylproline 1-Methyl-L-proline N-METHYL-L-PROLINE N-ME-PRO-OH 475-11-6 I - Z Modified Amino Acids Biochemicals and Reagents BioChemical Amino Acids and Peptides amino acids Amino Acids I - Z Modified Amino Acids