Fmoc-Pro-OH
- CAS No.
- 71989-31-6
- Chemical Name:
- Fmoc-Pro-OH
- Synonyms
- FMOC-PRO-OH;FMOC-PRO;FMOC-L-;FMOC-L-PRO-OH;FMOC-L-PRO;FMOC-PRO-OH H2O;FMOC-PROLINE;L-PROLINE-N-FMOC;FMOC-L-PRO-OH H2O;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PYRROLIDINE-2-CARBOXYLIC ACID
- CBNumber:
- CB8189794
- Molecular Formula:
- C20H19NO4
- Molecular Weight:
- 337.37
- MOL File:
- 71989-31-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/2 16:51:54
| Melting point | 117-118 °C(lit.) |
|---|---|
| alpha | -32 º (c=1,DMF) |
| Boiling point | 473.68°C (rough estimate) |
| Density | 1.2486 (rough estimate) |
| refractive index | -32.5 ° (C=1, DMF) |
| storage temp. | Store below +30°C. |
| solubility | Soluble in methanol. (almost transparency.) |
| pka | 3.95±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]20/D 32±1°, c = 1% in DMF |
| BRN | 3596735 |
| Concentration | 0.1 mCi/ml |
| Solvent | Ethanol |
| Specific Activity | 50-60 mCi/mmol |
| CAS DataBase Reference | 71989-31-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933 99 80 | |||||||||
| NFPA 704 |
|
Fmoc-Pro-OH price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.52017 | Fmoc-Pro-OH Novabiochem? | 71989-31-6 | 25G | ₹2920 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.52017 | Fmoc-Pro-OH Novabiochem? | 71989-31-6 | 100G | ₹4449.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.52017 | Fmoc-Pro-OH Novabiochem? | 71989-31-6 | 250G | ₹10330 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.52017 | Fmoc-Pro-OH Novabiochem? | 71989-31-6 | 8520170500 | ₹18580 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 47636 | Fmoc-Pro-OH ≥99.0% (HPLC) | 71989-31-6 | 5G | ₹2987.7 | 2022-06-14 | Buy |
Fmoc-Pro-OH Chemical Properties,Uses,Production
Description
Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.
Chemical Properties
white to light yellow crystal powder.
Uses
L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
Preparation
To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).
General Description
The product number for this product was previously 04-12-1031.
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Fmoc-Pro-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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